Exposure to permethrin used as a home insecticide: A case study comparing model predictions and excretion of metabolites
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Seon-Kyung | - |
dc.contributor.author | Lee, Heon-Jun | - |
dc.contributor.author | Song, Eugene | - |
dc.contributor.author | Kim, Yoonsub | - |
dc.contributor.author | Kim, Du Yung | - |
dc.contributor.author | Lee, Jong-Hyeon | - |
dc.contributor.author | Yoo, Hyun Jung | - |
dc.contributor.author | Oh, Jeong-Eun | - |
dc.contributor.author | Kwon, Jung-Hwan | - |
dc.date.accessioned | 2022-02-17T14:40:23Z | - |
dc.date.available | 2022-02-17T14:40:23Z | - |
dc.date.created | 2022-02-09 | - |
dc.date.issued | 2021-10 | - |
dc.identifier.issn | 0160-4120 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/136110 | - |
dc.description.abstract | Pyrethroids have been widely used as an active ingredient in home insecticide products since the 1960 s. Although their occurrence in indoor environments has been studied, the contribution of home insecticide application to the aggregate exposure to pyrethroids is not well known. The objective of this study was to estimate the consumer exposure to permethrin, a representative pyrethroid, via the use of home insecticide spray during the summer season using biomonitoring and personal exposure modeling. Exposure to permethrin was assessed by analyzing its urinary metabolites, 3-phenoxybenzoic acid (3-PBA) and cis/trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropan carboxylic acid (cis/trans-DCCA), for a group of consumers (n = 27). The levels of metabolites were also compared with those predicted by a screening exposure model considering personal exposure parameters. The levels of metabolites in 15 participants increased significantly (p < 0.05) with the application of home insecticide products, thereby suggesting that the heavy use of home insecticides during summer could be an important exposure route of permethrin in addition to other sources, such as food consumption. The total amount of excreted 3-PBA and cis/trans-DCCA was lower than the amount estimated by the exposure model for most participants by a factor of 0.9-861.0. These differences could be attributed to the rapid loss of permethrin after application, including sorption to indoor surfaces, reaction with indoor substances, individual biological variations, and ventilation during application. However, the screening exposure model used for the initial safety assessment of biocidal products generally performed well because it did not underestimate the personal exposure to permethrin during the application of home insecticide spray. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | HUMAN DOSE-EXCRETION | - |
dc.subject | AIR CHANGE RATES | - |
dc.subject | PYRETHROID INSECTICIDES | - |
dc.subject | URINARY CONCENTRATIONS | - |
dc.subject | POPULATION | - |
dc.subject | ORGANOPHOSPHATE | - |
dc.subject | PESTICIDES | - |
dc.subject | BIOMARKERS | - |
dc.subject | PROFILES | - |
dc.subject | BEHAVIOR | - |
dc.title | Exposure to permethrin used as a home insecticide: A case study comparing model predictions and excretion of metabolites | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kwon, Jung-Hwan | - |
dc.identifier.doi | 10.1016/j.envint.2021.106581 | - |
dc.identifier.scopusid | 2-s2.0-85104871786 | - |
dc.identifier.wosid | 000679250700010 | - |
dc.identifier.bibliographicCitation | ENVIRONMENT INTERNATIONAL, v.155 | - |
dc.relation.isPartOf | ENVIRONMENT INTERNATIONAL | - |
dc.citation.title | ENVIRONMENT INTERNATIONAL | - |
dc.citation.volume | 155 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Environmental Sciences & Ecology | - |
dc.relation.journalWebOfScienceCategory | Environmental Sciences | - |
dc.subject.keywordPlus | AIR CHANGE RATES | - |
dc.subject.keywordPlus | BEHAVIOR | - |
dc.subject.keywordPlus | BIOMARKERS | - |
dc.subject.keywordPlus | HUMAN DOSE-EXCRETION | - |
dc.subject.keywordPlus | ORGANOPHOSPHATE | - |
dc.subject.keywordPlus | PESTICIDES | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordPlus | PROFILES | - |
dc.subject.keywordPlus | PYRETHROID INSECTICIDES | - |
dc.subject.keywordPlus | URINARY CONCENTRATIONS | - |
dc.subject.keywordAuthor | Consumer exposure | - |
dc.subject.keywordAuthor | Insecticides | - |
dc.subject.keywordAuthor | Intervention study | - |
dc.subject.keywordAuthor | Permethrin | - |
dc.subject.keywordAuthor | Pyrethroids | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.