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Trend change of nasopharyngeal colonization with Streptococcus pneumoniae and non-typeable Haemophilus influenzae in children attending daycare centres: nationwide population-based study, South Korea 2014 and 2019

Authors
Choe, Young JuneHan, Mi SeonChoi, Youn YoungSohn, Young JooKim, Ye KyungKim, Kyung MinPark, Ji YoungKang, Hyun MiYoon, In AeChoi, Jae HongOh, Chi EunCho, Eun YoungLee, HyunjuChoi, Eun Hwa
Issue Date
10월-2021
Publisher
ELSEVIER SCI LTD
Keywords
Carriage; Children; Haemophilus influenzae; NTHi; Pneumococcus; Streptococcus pneumoniae; Vaccine
Citation
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, v.111, pp.328 - 332
Indexed
SCIE
SCOPUS
Journal Title
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
Volume
111
Start Page
328
End Page
332
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/136167
DOI
10.1016/j.ijid.2021.08.065
ISSN
1201-9712
Abstract
Background: Nasopharyngeal (NP) colonization with Streptococcus pneumoniae and non-typeable Haemophilus influenzae (NTHi) is common in children, and may evolve as the source of invasive infec-tions. In Korea, the pneumococcal conjugate vaccines (PCVs) were introduced > 10 years ago, enabling the authors to study the effect of the vaccine in preventing carriage. Methods: NP swabs were taken and a household survey was conducted at daycare centres located in different regions of Korea in 2014 and 2019. Pneumococcal serotypes were identified using the Quellung method and sequencing. NTHi were identified based on pilA and bexA genes. Results: In total, 1460 NP swabs were obtained with pneumococcal carriage rates of 36.4-42.1% and NTHi carriage rates of 36.5-26.7%. Among children carrying pneumococci, a significant increase was seen in serotype 23A between 2014 and 2019 (from 12.6% to 22.0%; P = 0.005). Children who had received PCV were at lower risk of vaccine-type carriage (2.9% vs 0.8%; P = 0.005). Conclusions: Between 2014 and 2019, the proportion of children carrying serotype 23A increased sig-nificantly, while the carriage rate of NTHi decreased. Continuous surveillance is needed to assess the long-term effects of the PCVs on carriage dynamics of pneumococcus and NTHi. (c) 2021 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )
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