Synthesis and evaluation of curcumin-based near-infrared fluorescent probes for the in vivo optical imaging of amyloid-beta plaques
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Yong Dae | - |
dc.contributor.author | Kinger, Mayank | - |
dc.contributor.author | Min, Changho | - |
dc.contributor.author | Lee, Sang Yeob | - |
dc.contributor.author | Byun, Youngjoo | - |
dc.contributor.author | Park, Jin Woo | - |
dc.contributor.author | Jeon, Jongho | - |
dc.date.accessioned | 2022-02-18T12:40:34Z | - |
dc.date.available | 2022-02-18T12:40:34Z | - |
dc.date.created | 2022-02-08 | - |
dc.date.issued | 2021-10 | - |
dc.identifier.issn | 0045-2068 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/136221 | - |
dc.description.abstract | The abnormal self-assembly of amyloid-beta (A beta) peptides into oligomers, as well as insoluble fibrils, has been identified as a key factor for monitoring the progression of Alzheimer's disease (AD). The noninvasive imaging of A beta aggregates utilizing chemical probes can be a powerful and practical technique for accurately diagnosing and monitoring the progress of AD, as well as evaluating the effectiveness of therapeutic drug candidates in treating or managing it. Particularly, the near-infrared (NIR) fluorescence imaging of A beta plaques is a potentially promising approach toward the efficient detection of the biomarker. In this study, we describe a new NIR fluorophore, which was based on curcumin derivatives. The fluorophore is equipped with desirable optical properties for in vivo brain imaging. The emission wavelength of the probe, 8b, is 667 nm, and its fluorescent intensity is significantly increased through binding with the A beta aggregates. The probe allows the clear visualization of the A beta plaques 10 min post administration, and the intensity of the fluorescent signal in the brain of a 5XFAD transgenic mouse model is more than three times higher than that of the normal control group. These results demonstrate that the designed probe can be an effective tool for visualizing A beta plaques, as well as investigating the pathological progress of AD. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | ALZHEIMERS-DISEASE | - |
dc.subject | EARLY-DIAGNOSIS | - |
dc.subject | CROSS-LINKING | - |
dc.subject | BIOMARKERS | - |
dc.title | Synthesis and evaluation of curcumin-based near-infrared fluorescent probes for the in vivo optical imaging of amyloid-beta plaques | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Byun, Youngjoo | - |
dc.identifier.doi | 10.1016/j.bioorg.2021.105167 | - |
dc.identifier.scopusid | 2-s2.0-85111690367 | - |
dc.identifier.wosid | 000704367300012 | - |
dc.identifier.bibliographicCitation | BIOORGANIC CHEMISTRY, v.115 | - |
dc.relation.isPartOf | BIOORGANIC CHEMISTRY | - |
dc.citation.title | BIOORGANIC CHEMISTRY | - |
dc.citation.volume | 115 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | BIOMARKERS | - |
dc.subject.keywordPlus | CROSS-LINKING | - |
dc.subject.keywordPlus | EARLY-DIAGNOSIS | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | Curcumin | - |
dc.subject.keywordAuthor | Diagnosis | - |
dc.subject.keywordAuthor | Fluorescent probe | - |
dc.subject.keywordAuthor | In vivo imaging | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.