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Alterations in the Occipital Cortex of Drug-Naive Adults With Major Depressive Disorder: A Surface-Based Analysis of Surface Area and Cortical Thickness

Authors
Lee, Jee SooKang, WooyoungKang, YoubinKim, AramHan, Kyu-ManTae, Woo-SukHam, Byung-Joo
Issue Date
10월-2021
Publisher
KOREAN NEUROPSYCHIATRIC ASSOC
Keywords
Cortical thickness; Major depressive disorder; Occipital cortex; Surface area
Citation
PSYCHIATRY INVESTIGATION, v.18, no.10, pp.1025 - +
Indexed
SCIE
SSCI
SCOPUS
KCI
Journal Title
PSYCHIATRY INVESTIGATION
Volume
18
Number
10
Start Page
1025
End Page
+
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/136230
DOI
10.30773/pi.2021.0099
ISSN
1738-3684
Abstract
Objective Advances in surface-based morphometric methods have allowed researchers to separate cortical volume into cortical thickness (CTh) and surface area (SA). Although CTh alterations in major depressive disorder (MDD) have been observed in numerous studies, few studies have described significant SA alterations. Our study aimed to measure patients' SAs and to compare it with their CTh to examine whether SA exhibits alteration patterns that differ from those of CTh in drug-naive patients with MDD. Methods A total of 71 drug-naive MDD patients and 111 healthy controls underwent structural magnetic resonance imaging, and SA and CTh were analyzed between the groups. Results We found a smaller SA in the left superior occipital gyrus (L-SOG) in drug-naive patients with MDD. In the CTh analysis, the bilateral fusiform gyrus, left middle occipital gyrus, left temporal superior gyrus, and right posterior cingulate showed thinner cortices in patients with MDD, while the CTh of the bilateral SOG, right straight gyrus, right posterior cingulate, and left lingual gyrus were increased. Conclusion Compared with the bilateral occipito-temporal changes in CTh, SA alterations in patients with MDD were confined to the L-SOG. These findings may improve our understanding of the neurobiological mechanisms of SA alteration in relation to MDD. Psychiatry Investig 2021;18(1):1025-1033
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