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Novel Paju Apodemus paramyxovirus 1 and 2, harbored by Apodemus agrarius in the Republic of Korea

Authors
Lee, Seung-HoNo, Jin SunKim, KijinBudhathoki, ShaileshPark, KyungminLee, Geum-YoungCho, SeungchanKim, Bong-HyunCho, SeungheeKim, JongwooLee, JingyeongCho, Seung HyeKim, Heung-ChulKlein, Terry A.Uhm, Chang-SubKim, Won-KeunSong, Jin-Won
Issue Date
10월-2021
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Keywords
Apodemus agrarius; Paju Apodemus paramyxovirus 1; Paju Apodemus paramyxovirus 2; Phylogenetic diversity; Rodent paramyxovirus
Citation
VIROLOGY, v.562, pp.40 - 49
Indexed
SCIE
SCOPUS
Journal Title
VIROLOGY
Volume
562
Start Page
40
End Page
49
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/136236
DOI
10.1016/j.virol.2021.06.011
ISSN
0042-6822
Abstract
Paramyxoviruses harbored by multiple natural reservoirs pose a potential threat to public health. Jeilongvirus has been proposed as a novel paramyxovirus genus found in rodents, bats, and cats. Paramyxovirus RNA was detected in 108/824 (13.1%) Apodemus agrarius captured at 14 trapping sites in the Republic of Korea. We first present two genetically distinct novel paramyxoviruses, Paju Apodemus paramyxovirus 1 (PAPV-1) and 2 (PAPV2). The disparity between PAPV-1 (19,716 nucleotides) and-2 (17,475 nucleotides) revealed the presence of the SH gene and length of the G gene in the genome organization. The phylogeny of PAPV-1 and-2 belonged to distinct genetic lineages of Jeilongvirus, respectively, even though these viruses were originated from A. agrarius. PAPV-1 infected human epithelial and endothelial cells, facilitating the induction of type I/III interferons, interferon-stimulated genes, and pro-inflammatory cytokines. Therefore, this study provides insights into the molecular epidemiology, genetic diversity, and virus-host interactions of novel rodent-borne paramyxoviruses.
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