The effects of cerebral amyloidopathy on regional glucose metabolism in older adults with depression and mild cognitive impairment while performing memory tasks
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Eun Seong | - |
dc.contributor.author | Youn, HyunChul | - |
dc.contributor.author | Hyung, Won Seok William | - |
dc.contributor.author | Suh, Sangil | - |
dc.contributor.author | Han, Cheol E. | - |
dc.contributor.author | Eo, Jae Seon | - |
dc.contributor.author | Jeong, Hyun-Ghang | - |
dc.date.accessioned | 2022-02-18T18:40:52Z | - |
dc.date.available | 2022-02-18T18:40:52Z | - |
dc.date.created | 2022-02-08 | - |
dc.date.issued | 2021-10 | - |
dc.identifier.issn | 0953-816X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/136251 | - |
dc.description.abstract | Co-occurring depression and mild cognitive impairment (MCI) in older adults are important because they have a high risk of conversion to dementia. In the present study, task-related F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) was used to analyse older adults with concomitant depression and MCI. We recruited 20 older adults with simultaneous depression and MCI and 10 older adults with normal cognition (NC). The Verbal Paired Associates test and digit span test were used for the task-related FDG-PET. The 20 older adults with depression and MCI were classified into two groups based on the F-18 florbetaben PET results: depressed MCI patients with (LLD-MCI-A[+]; n = 11) and without amyloid accumulation (LLD-MCI-A[-]; n = 9). Reduced regional cerebral glucose metabolism (rCMglc) in the left superior frontal region was observed in the LLD-MCI-A(-) group compared with the NC group. Analyses of the NC and LLD-MCI-A(+) groups showed significantly decreased rCMglc in the right inferior parietal and left middle frontal regions in the LLD-MCI-A(+) group. rCMglc in the left precuneus was lower in the LLD-MCI-A(+) group than in the LLD-MCI-A(-) group. Significant correlations between the rCMglc in the right inferior parietal/left precuneus regions and memory task scores were observed based on correlation analyses of NC and LLD-MCI-A(+) groups. The findings in the present study indicate the presence of amyloid accumulation influences glucose metabolism in depressed elderly subjects with MCI while performing cognitive tasks. Task-related FDG-PET examinations may help differentiate MCI associated with depression from comorbid depression in patients with prodromal Alzheimer's disease. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | INFERIOR FRONTAL-CORTEX | - |
dc.subject | ALZHEIMERS-DISEASE | - |
dc.subject | BRAIN | - |
dc.subject | FDG | - |
dc.subject | DYSFUNCTION | - |
dc.subject | PARIETAL | - |
dc.subject | FMRI | - |
dc.subject | ABNORMALITIES | - |
dc.subject | ATTENTION | - |
dc.subject | SYMPTOMS | - |
dc.title | The effects of cerebral amyloidopathy on regional glucose metabolism in older adults with depression and mild cognitive impairment while performing memory tasks | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Suh, Sangil | - |
dc.contributor.affiliatedAuthor | Han, Cheol E. | - |
dc.identifier.doi | 10.1111/ejn.15461 | - |
dc.identifier.scopusid | 2-s2.0-85115798934 | - |
dc.identifier.wosid | 000700327100001 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF NEUROSCIENCE, v.54, no.7, pp.6663 - 6672 | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF NEUROSCIENCE | - |
dc.citation.title | EUROPEAN JOURNAL OF NEUROSCIENCE | - |
dc.citation.volume | 54 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 6663 | - |
dc.citation.endPage | 6672 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | ABNORMALITIES | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | ATTENTION | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
dc.subject.keywordPlus | FDG | - |
dc.subject.keywordPlus | FMRI | - |
dc.subject.keywordPlus | INFERIOR FRONTAL-CORTEX | - |
dc.subject.keywordPlus | PARIETAL | - |
dc.subject.keywordPlus | SYMPTOMS | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | FDG-PET | - |
dc.subject.keywordAuthor | amyloid | - |
dc.subject.keywordAuthor | depression | - |
dc.subject.keywordAuthor | hypometabolism | - |
dc.subject.keywordAuthor | mild cognitive impairment | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.