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Emergence of serotype 10A-ST11189 among pediatric invasive pneumococcal diseases, South Korea, 2014-2019

Authors
Yun, Ki WookRhie, KyuyolKang, Jin HanKim, Kyung-HyoAhn, Jong GyunKim, Yae-JeanEun, Byung WookOh, Sung HeeCho, Hye-KyungHong, Young JinKim, Nam HeeKim, Yun-KyungLee, HyunjuLee, TaekjinKim, Hwang MinCho, Eun YoungKim, Chun SooPark, Su EunOh, Chi EunJo, Dae SunSong, Eun SongLee, JinaChoi, Jae HongLee, Joon KeeLee, Hoan JongChoi, Eun Hwa
Issue Date
24-9월-2021
Publisher
ELSEVIER SCI LTD
Keywords
Children; Genotype; Serotype; Streptococcus pneumoniae
Citation
VACCINE, v.39, no.40, pp.5787 - 5793
Indexed
SCIE
SCOPUS
Journal Title
VACCINE
Volume
39
Number
40
Start Page
5787
End Page
5793
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/136308
DOI
10.1016/j.vaccine.2021.08.072
ISSN
0264-410X
Abstract
Replacement with nonvaccine serotypes (NVTs) among invasive pneumococcal diseases (IPDs) after the introduction of extended-valency pneumococcal conjugate vaccines varies in predominant serotypes across countries. This study analyzed changes in serotype distribution through serotyping, multilocus sequence typing, and antimicrobial susceptibility testing of 168 pediatric IPD isolates obtained from a multihospital-based surveillance system during 2014-2019 in South Korea. Vaccine serotypes (VTs) accounted for 16.1% (19A, 10.1%; 6A, 1.8%; and 19F 1.8%), 82.1% were NVTs (10A, 23.8%; 15A, 8.3%; 12F, 6.5%; 15C, 6.5%; and 15B, 6.0%), and three (1.8%) were nontypeable. Serotype 10A was the most com-mon serotype, with a significant increase from 11.5% in 2014 to 33.3% in 2019 (p < 0.05 for the trend). Other NVTs decreased from 70.4% to 41.7% between 2015 and 2019, most notably in serotype 12F (from 14.8% to 0%). Almost all (95.0%) serotype 10A isolates were ST11189, which were multidrug resistant. (c) 2021 Elsevier Ltd. All rights reserved.
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