Generation of a more efficient prime editor 2 by addition of the Rad51 DNA-binding domain
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song, Myungjae | - |
dc.contributor.author | Lim, Jung Min | - |
dc.contributor.author | Min, Seonwoo | - |
dc.contributor.author | Oh, Jeong-Seok | - |
dc.contributor.author | Kim, Dong Young | - |
dc.contributor.author | Woo, Jae-Sung | - |
dc.contributor.author | Nishimasu, Hiroshi | - |
dc.contributor.author | Cho, Sung-Rae | - |
dc.contributor.author | Yoon, Sungroh | - |
dc.contributor.author | Kim, Hyongbum Henry | - |
dc.date.accessioned | 2022-02-19T04:41:33Z | - |
dc.date.available | 2022-02-19T04:41:33Z | - |
dc.date.created | 2022-02-08 | - |
dc.date.issued | 2021-09-23 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/136311 | - |
dc.description.abstract | Although prime editing is a promising genome editing method, the efficiency of prime editor 2 (PE2) is often insufficient. Here we generate a more efficient variant of PE2, named hyPE2, by adding the Rad51 DNA-binding domain. When tested at endogenous sites, hyPE2 shows a median of 1.5- or 1.4- fold (range, 0.99- to 2.6-fold) higher efficiencies than PE2; furthermore, at sites where PE2-induced prime editing is very inefficient (efficiency < 1%), hyPE2 enables prime editing with efficiencies ranging from 1.1% to 2.9% at up to 34% of target sequences, potentially facilitating prime editing applications. While prime editing is a promising technology, PE2 systems often have low efficiency. Here the authors fuse a Rad51 DNA-binding domain to create hyPE2 with improved editing efficiency. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PORTFOLIO | - |
dc.title | Generation of a more efficient prime editor 2 by addition of the Rad51 DNA-binding domain | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Woo, Jae-Sung | - |
dc.identifier.doi | 10.1038/s41467-021-25928-2 | - |
dc.identifier.scopusid | 2-s2.0-85115650595 | - |
dc.identifier.wosid | 000698773500004 | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, v.12, no.1 | - |
dc.relation.isPartOf | NATURE COMMUNICATIONS | - |
dc.citation.title | NATURE COMMUNICATIONS | - |
dc.citation.volume | 12 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
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