A nationwide study of patients with monoclonal gammopathy of undetermined significance with a 10-year follow-up in South Korea
DC Field | Value | Language |
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dc.contributor.author | Kang, Ka-Won | - |
dc.contributor.author | Song, Ji Eun | - |
dc.contributor.author | Lee, Byung-Hyun | - |
dc.contributor.author | Jeon, Min Ji | - |
dc.contributor.author | Yu, Eun Sang | - |
dc.contributor.author | Kim, Dae Sik | - |
dc.contributor.author | Lee, Se Ryeon | - |
dc.contributor.author | Sung, Hwa Jung | - |
dc.contributor.author | Choi, Chul Won | - |
dc.contributor.author | Park, Yong | - |
dc.contributor.author | Kim, Byung Soo | - |
dc.date.accessioned | 2022-02-21T05:41:41Z | - |
dc.date.available | 2022-02-21T05:41:41Z | - |
dc.date.created | 2022-02-08 | - |
dc.date.issued | 2021-09-16 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/136344 | - |
dc.description.abstract | In clinical practice, most patients with monoclonal gammopathy of undetermined significance (MGUS) undergo long-term follow-up without disease progression. There is insufficient real-world data about how closely and whether anything other than disease progression should be monitored. Herein, we performed a nationwide study of 470 patients with MGUS with a 10-year follow-up to determine the patterns of disease progression and other comorbidities. During the follow-up period, 158 of 470 patients with MGUS (33.62%) progressed to symptomatic monoclonal gammopathies. Most of these were multiple myeloma (134/470 patients, 28.51%), and those diagnosed within 2 years after diagnosis of MGUS was high. Approximately 30-50% of patients with MGUS had hypertension, diabetes, hyperlipidemia, and osteoarthritis at the time of diagnosis, and these comorbidities were newly developed during the follow-up period in approximately 50% of the remaining patients with MGUS. Approximately 20-40% of patients with MGUS have acute or chronic kidney failure, thyroid disorders, disc disorders, peripheral neuropathy, myocardial infarction, stroke, and heart failure during the follow-up period. Altogether, when MGUS is diagnosed, close follow-up of the possibility of progression to multiple myeloma is required, especially within 2 years after diagnosis; simultaneously, various comorbidities should be considered and monitored during the follow-up of patients with MGUS. Continuous research is needed to establish appropriate follow-up guidelines. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PORTFOLIO | - |
dc.subject | SIGNIFICANCE MGUS | - |
dc.subject | MULTIPLE-MYELOMA | - |
dc.subject | LONG-TERM | - |
dc.subject | PREVALENCE | - |
dc.subject | POPULATION | - |
dc.subject | EPIDEMIOLOGY | - |
dc.subject | PATHOGENESIS | - |
dc.subject | PROGRESSION | - |
dc.subject | CANCER | - |
dc.subject | RISK | - |
dc.title | A nationwide study of patients with monoclonal gammopathy of undetermined significance with a 10-year follow-up in South Korea | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kang, Ka-Won | - |
dc.contributor.affiliatedAuthor | Kim, Dae Sik | - |
dc.contributor.affiliatedAuthor | Choi, Chul Won | - |
dc.contributor.affiliatedAuthor | Park, Yong | - |
dc.identifier.doi | 10.1038/s41598-021-97664-y | - |
dc.identifier.scopusid | 2-s2.0-85115276050 | - |
dc.identifier.wosid | 000696635300060 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.11, no.1 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 11 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | EPIDEMIOLOGY | - |
dc.subject.keywordPlus | LONG-TERM | - |
dc.subject.keywordPlus | MULTIPLE-MYELOMA | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | SIGNIFICANCE MGUS | - |
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