Association between body temperature and leukocyte telomere length in Korean middle-aged and older adults
DC Field | Value | Language |
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dc.contributor.author | Garcia-Garcia, Carolina | - |
dc.contributor.author | Shin, Chol | - |
dc.contributor.author | Baik, Inkyung | - |
dc.date.accessioned | 2022-02-21T11:42:13Z | - |
dc.date.available | 2022-02-21T11:42:13Z | - |
dc.date.created | 2022-02-08 | - |
dc.date.issued | 2021-09-08 | - |
dc.identifier.issn | 1225-3596 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/136376 | - |
dc.description.abstract | OBJECTIVES: Data on associations between body temperature (BT) and leukocyte telomere length (LTL), which has been widely used as a biomarker of cellular senescence in recent epidemiological studies, are limited. Therefore, this study aimed to explore the associations between a normal BT range (35.0-37.5 degrees C) and LTL via 6-year longitudinal observations of 2,004 male and female adults aged 50 or older. METHODS: BT was obtained by measuring the tympanic temperature, and relative LTL was determined by real-time polymerase chain reaction. Robust regression analysis was used to evaluate the association between the baseline and follow-up LTL values and their differences. RESULTS: A significant inverse association was found between BT and LTL at baseline. The regression coefficient estimate was-0.03 (95% confidence interval, -0.07 to-0.001; p < 0.05). This association was stronger in participants with a body mass index 25 kg/m(2) and males (p < 0.01). However, there were no associations between BT and LTL at follow-up or BT and 6-year longitudinal differences in LTL. CONCLUSIONS: These findings suggest that having a high BT between 35 degrees C and 37.5 degrees C (95 degrees F and 99 degrees F) may be detrimental for obese individuals in terms of biological aging. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC EPIDEMIOLOGY | - |
dc.subject | CALORIC RESTRICTION | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | LONGEVITY | - |
dc.subject | LIFE | - |
dc.subject | CONSUMPTION | - |
dc.subject | BIOMARKERS | - |
dc.subject | OBESITY | - |
dc.title | Association between body temperature and leukocyte telomere length in Korean middle-aged and older adults | - |
dc.title.alternative | Association between body temperature and leukocyte telomere length in middle-aged and older adults | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, Chol | - |
dc.identifier.doi | 10.4178/epih.e2021063 | - |
dc.identifier.scopusid | 2-s2.0-85121952510 | - |
dc.identifier.wosid | 000718047800001 | - |
dc.identifier.bibliographicCitation | EPIDEMIOLOGY AND HEALTH, v.43, pp.1 - 9 | - |
dc.relation.isPartOf | EPIDEMIOLOGY AND HEALTH | - |
dc.citation.title | EPIDEMIOLOGY AND HEALTH | - |
dc.citation.volume | 43 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 9 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002774960 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Public, Environmental & Occupational Health | - |
dc.relation.journalWebOfScienceCategory | Public, Environmental & Occupational Health | - |
dc.subject.keywordPlus | BIOMARKERS | - |
dc.subject.keywordPlus | CALORIC RESTRICTION | - |
dc.subject.keywordPlus | CONSUMPTION | - |
dc.subject.keywordPlus | LIFE | - |
dc.subject.keywordPlus | LONGEVITY | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordAuthor | Aging | - |
dc.subject.keywordAuthor | Body temperature | - |
dc.subject.keywordAuthor | Longitudinal study | - |
dc.subject.keywordAuthor | Obesity | - |
dc.subject.keywordAuthor | Telomere shortening | - |
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