Longitudinal Assessment of Antisevere Acute Respiratory Syndrome Coronavirus 2 Immune Responses for Six Months Based on the Clinical Severity of Coronavirus Disease 2019
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Noh, Ji Yun | - |
dc.contributor.author | Kwak, Jeong-Eun | - |
dc.contributor.author | Yang, Jeong-Sun | - |
dc.contributor.author | Hwang, Soon Young | - |
dc.contributor.author | Yoon, Jin Gu | - |
dc.contributor.author | Seong, Hye | - |
dc.contributor.author | Hyun, Hakjun | - |
dc.contributor.author | Lim, Chae Seung | - |
dc.contributor.author | Yoon, Soo-Young | - |
dc.contributor.author | Ryou, Jungsang | - |
dc.contributor.author | Lee, Joo-Yeon | - |
dc.contributor.author | Kim, Sung-Soon | - |
dc.contributor.author | Park, Su-Hyung | - |
dc.contributor.author | Cheong, Hee Jin | - |
dc.contributor.author | Kim, Woo Joo | - |
dc.contributor.author | Shin, Eui-Cheol | - |
dc.contributor.author | Song, Joon Young | - |
dc.date.accessioned | 2022-02-21T17:41:59Z | - |
dc.date.available | 2022-02-21T17:41:59Z | - |
dc.date.created | 2022-02-07 | - |
dc.date.issued | 2021-09-01 | - |
dc.identifier.issn | 0022-1899 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/136405 | - |
dc.description.abstract | Background. There is insufficient data on the longevity of immunity acquired after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Methods. We aimed to evaluate the duration of SARS-CoV-2-specific humoral and cellular immunity according to the clinical severity of coronavirus disease 2019 (COVID-19). The study population comprised asymptomatic (n = 14), symptomatic/ nonpneumonic (n = 42), and pneumonic (n = 41) patients. Results. The anti-SARS-CoV-2 immunoglobulin class G and neutralizing antibody (NAb) titers lasted until 6 months after diagnosis, with positivity rates of 66.7% and 86.9%, respectively. Older age, prolonged viral shedding, and accompanying pneumonia were more frequently found in patients with sustained humoral immunity. Severe acute respiratory syndrome coronavirus 2-specific T-cell response was strongly observed in pneumonic patients and prominent in individuals with sustained humoral immunity. Conclusions. In conclusion, most (>85%) patients carry NAb until 6 months after diagnosis of SARS-CoV-2 infection, providing insights for establishing vaccination strategies against COVID-19. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS INC | - |
dc.title | Longitudinal Assessment of Antisevere Acute Respiratory Syndrome Coronavirus 2 Immune Responses for Six Months Based on the Clinical Severity of Coronavirus Disease 2019 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Noh, Ji Yun | - |
dc.contributor.affiliatedAuthor | Lim, Chae Seung | - |
dc.contributor.affiliatedAuthor | Cheong, Hee Jin | - |
dc.contributor.affiliatedAuthor | Kim, Woo Joo | - |
dc.contributor.affiliatedAuthor | Song, Joon Young | - |
dc.identifier.doi | 10.1093/infdis/jiab124 | - |
dc.identifier.scopusid | 2-s2.0-85107041479 | - |
dc.identifier.wosid | 000703933800003 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INFECTIOUS DISEASES, v.224, no.5, pp.754 - 763 | - |
dc.relation.isPartOf | JOURNAL OF INFECTIOUS DISEASES | - |
dc.citation.title | JOURNAL OF INFECTIOUS DISEASES | - |
dc.citation.volume | 224 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 754 | - |
dc.citation.endPage | 763 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.subject.keywordAuthor | COVID-19 | - |
dc.subject.keywordAuthor | SARS-CoV-2 | - |
dc.subject.keywordAuthor | cellular immunity | - |
dc.subject.keywordAuthor | humoral immunity | - |
dc.subject.keywordAuthor | longevity | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.