Long-term outcomes of undifferentiated-type early gastric cancer with positive horizontal margins after endoscopic resection
DC Field | Value | Language |
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dc.contributor.author | Yang, H.-J. | - |
dc.contributor.author | Lee, W.-S. | - |
dc.contributor.author | Lee, B.E. | - |
dc.contributor.author | Ahn, J.Y. | - |
dc.contributor.author | Jang, J.-Y. | - |
dc.contributor.author | Lim, J.H. | - |
dc.contributor.author | Nam, S.Y. | - |
dc.contributor.author | Kim, J.-H. | - |
dc.contributor.author | Min, B.-H. | - |
dc.contributor.author | Joo, M.K. | - |
dc.contributor.author | Park, J.M. | - |
dc.contributor.author | Shin, W.G. | - |
dc.contributor.author | Lee, H.L. | - |
dc.contributor.author | Gweon, T.-G. | - |
dc.contributor.author | Park, M.I. | - |
dc.contributor.author | Choi, J. | - |
dc.contributor.author | Tae, C.H. | - |
dc.contributor.author | Kim, Y.-I. | - |
dc.contributor.author | Choi, I.J. | - |
dc.date.accessioned | 2022-02-21T17:42:50Z | - |
dc.date.available | 2022-02-21T17:42:50Z | - |
dc.date.created | 2022-02-09 | - |
dc.date.issued | 2021-09 | - |
dc.identifier.issn | 1976-2283 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/136408 | - |
dc.description.abstract | Background/Aims: This study examined the long-term outcomes of undifferentiated-type early gastric cancer (UD EGC) with positive horizontal margins (HMs) after endoscopic resection (ER) and compared them between additional surgery and nonsurgical management. Methods: From 2005 to 2015, a total of 1,124 patients with UD EGC underwent ER at 18 tertiary hospitals in Korea. Of them, 92 patients with positive HMs as the only noncurative factor (n=25) or with both positive HMs and tumor size >2 cm (n=67) were included. These patients underwent additional surgery (n=40), underwent additional endoscopic treatment (n=6), or were followed up without further treatment (n=46). Results: No lymph node (LN) metastasis was found in patients who underwent additional surgery. During a median follow-up of 57.7 months (interquartile range, 27.6 to 68.8 months), no LN or distant metastases or gastric cancer-related deaths occurred in the overall cohort. At baseline, the residual cancer rate was 57.8% (26/45) after additional surgery or ER. The 5-year local recurrence rate was 33.6% among patients who were followed up without additional treatment. The 5-year overall survival rates were 95.0% and 87.8% after additional surgery and nonsurgical management (endoscopic treatment or close follow-up), respectively (log-rank p=0.224). In the multivariate Cox regression analysis, nonsurgical management was not associated with an increased risk of mortality. Conclusions: UD EGC with positive HMs after ER may have favorable long-term outcomes and a very low risk of LN metastasis. Nonsurgical management may be suggested as an alternative, particularly for patients with old age or chronic illness. © 2021 Editorial Office of Gut and Liver. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | Editorial Office of Gut and Liver | - |
dc.title | Long-term outcomes of undifferentiated-type early gastric cancer with positive horizontal margins after endoscopic resection | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Joo, M.K. | - |
dc.identifier.doi | 10.5009/gnl20291 | - |
dc.identifier.scopusid | 2-s2.0-85115217950 | - |
dc.identifier.wosid | 000736815600002 | - |
dc.identifier.bibliographicCitation | Gut and Liver, v.15, no.5, pp.723 - 731 | - |
dc.relation.isPartOf | Gut and Liver | - |
dc.citation.title | Gut and Liver | - |
dc.citation.volume | 15 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 723 | - |
dc.citation.endPage | 731 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002755549 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | CLINICAL-OUTCOMES | - |
dc.subject.keywordPlus | LATERAL MARGIN | - |
dc.subject.keywordPlus | LYMPH-NODE METASTASIS | - |
dc.subject.keywordPlus | RISK-FACTORS | - |
dc.subject.keywordPlus | SUBMUCOSAL DISSECTION | - |
dc.subject.keywordAuthor | Endoscopic mucosal resection | - |
dc.subject.keywordAuthor | Lymphatic metastasis | - |
dc.subject.keywordAuthor | Margins of excision | - |
dc.subject.keywordAuthor | Stomach neoplasms | - |
dc.subject.keywordAuthor | Undifferentiated-type histology | - |
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