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Immunoregulation of Macrophages by Controlling Winding and Unwinding of Nanohelical Ligands

Authors
Bae, GunhyuJeon, Yoo SangKo, Min JunKim, YuriHan, Seong-BeomThangam, RamarKim, WonsikJung, Hee JoonLee, SungkyuChoi, HyojunMin, SunhongHong, HyunsikPark, SangwooKim, Seong YeolPatel, Kapil D.Li, NaShin, Jeong EunPark, Bum ChulPark, Hyeon SuMoon, Jun HwanKim, Yu JinSukumar, Uday KumarSong, Jae-JunKim, Soo YoungYu, Seung-HoKang, Yun ChanPark, SteveHan, Seung MinKim, Dong-HweeLee, Ki-BumWei, QiangBian, LimingPaulmurugan, RamasamyKim, Young KeunKang, Heemin
Issue Date
9월-2021
Publisher
WILEY-V C H VERLAG GMBH
Keywords
adhesion assembly; macrophage polarization; nanohelix motion; remote manipulation; reversible ligand unwinding
Citation
ADVANCED FUNCTIONAL MATERIALS, v.31, no.37
Indexed
SCIE
SCOPUS
Journal Title
ADVANCED FUNCTIONAL MATERIALS
Volume
31
Number
37
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/136428
DOI
10.1002/adfm.202103409
ISSN
1616-301X
Abstract
Developing materials with the capability of changing their innate features can help to unravel direct interactions between cells and ligand-displaying features. This study demonstrates the grafting of magnetic nanohelices displaying cell-adhesive Arg-Gly-Asp (RGD) ligand partly to a material surface. These enable nanoscale control of rapid winding ("W") and unwinding ("UW") of their nongrafted portion, such as directional changes in nanohelix unwinding (lower, middle, and upper directions) by changing the position of a permanent magnet while keeping the ligand-conjugated nanohelix surface area constant. The unwinding ("UW") setting cytocompatibility facilitates direct integrin recruitment onto the ligand-conjugated nanohelix to mediate the development of paxillin adhesion assemblies of macrophages that stimulate M2 polarization using glass and silicon substrates for in vitro and in vivo settings, respectively, at a single cell level. Real time and in vivo imaging are demonstrated that nanohelices exhibit reversible unwinding, winding, and unwinding settings, which modulate time-resolved adhesion and polarization of macrophages. It is envisaged that this remote, reversible, and cytocompatible control can help to elucidate molecular-level cell-material interactions that modulate regenerative/anti-inflammatory immune responses to implants.
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College of Medicine > Department of Medical Science > 1. Journal Articles
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공과대학 (신소재공학부)
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