Therapeutic Effects of Aripiprazole in the 5xFAD Alzheimer's Disease Mouse Model
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeong, Ye Ji | - |
dc.contributor.author | Son, Yeonghoon | - |
dc.contributor.author | Park, Hye-Jin | - |
dc.contributor.author | Oh, Se Jong | - |
dc.contributor.author | Choi, Jae Yong | - |
dc.contributor.author | Ko, Young-Gyu | - |
dc.contributor.author | Lee, Hae-June | - |
dc.date.accessioned | 2022-02-22T04:41:38Z | - |
dc.date.available | 2022-02-22T04:41:38Z | - |
dc.date.created | 2022-02-07 | - |
dc.date.issued | 2021-09 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/136459 | - |
dc.description.abstract | Global aging has led to growing health concerns posed by Alzheimer's disease (AD), the most common type of dementia. Aripiprazole is an atypical FDA-approved anti-psychotic drug with potential against AD. To investigate its therapeutic effects on AD pathology, we administered aripiprazole to 5xFAD AD model mice and examined beta-amyloid (beta A)-induced AD-like phenotypes, including beta A production, neuroinflammation, and cerebral glucose metabolism. Aripiprazole administration significantly decreased beta A accumulation in the brains of 5xFAD AD mice. Aripiprazole significantly modified amyloid precursor protein processing, including carboxyl-terminal fragment beta and beta A, a disintegrin and metalloproteinase domain-containing protein 10, and beta-site APP cleaving enzyme 1, as determined by Western blotting. Neuroinflammation, as evidenced by ionized calcium binding adapter molecule 1 and glial fibrillary acidic protein upregulation was dramatically inhibited, and the neuron cell layer of the hippocampal CA1 region was preserved following aripiprazole administration. In 18F-fluorodeoxyglucose positron emission tomography, after receiving aripiprazole, 5xFAD mice showed a significant increase in glucose uptake in the striatum, thalamus, and hippocampus compared to vehicle-treated AD mice. Thus, aripiprazole effectively alleviated beta A lesions and prevented the decline of cerebral glucose metabolism in 5xFAD AD mice, suggesting its potential for beta A metabolic modification and highlighting its therapeutic effect over AD progression. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | SAFETY | - |
dc.subject | BETA | - |
dc.subject | IMPAIRMENT | - |
dc.subject | PREDICTION | - |
dc.subject | F-18-FDG | - |
dc.subject | MICE | - |
dc.subject | PET | - |
dc.title | Therapeutic Effects of Aripiprazole in the 5xFAD Alzheimer's Disease Mouse Model | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ko, Young-Gyu | - |
dc.identifier.doi | 10.3390/ijms22179374 | - |
dc.identifier.scopusid | 2-s2.0-85113828773 | - |
dc.identifier.wosid | 000694351200001 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.22, no.17 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 22 | - |
dc.citation.number | 17 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | BETA | - |
dc.subject.keywordPlus | F-18-FDG | - |
dc.subject.keywordPlus | IMPAIRMENT | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | PET | - |
dc.subject.keywordPlus | PREDICTION | - |
dc.subject.keywordPlus | SAFETY | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease mice | - |
dc.subject.keywordAuthor | FDG-PET | - |
dc.subject.keywordAuthor | aripiprazole | - |
dc.subject.keywordAuthor | beta A pathology | - |
dc.subject.keywordAuthor | therapeutic agent | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.