Multicenter real-world data of patients harboring rare mutations other than EGFR or ALK in advanced or metastatic non-small cell lung cancer
DC Field | Value | Language |
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dc.contributor.author | Lee, Su Yeon | - |
dc.contributor.author | Kim, Young Chul | - |
dc.contributor.author | Lee, Kye Young | - |
dc.contributor.author | Lee, Sung Yong | - |
dc.contributor.author | Lee, Shin Yup | - |
dc.contributor.author | Lee, Min Ki | - |
dc.contributor.author | Lee, Jeong Eun | - |
dc.contributor.author | Jang, Seung Hun | - |
dc.contributor.author | Jang, Tae-Won | - |
dc.contributor.author | Choi, Chang Min | - |
dc.date.accessioned | 2022-02-22T14:42:37Z | - |
dc.date.available | 2022-02-22T14:42:37Z | - |
dc.date.created | 2022-02-11 | - |
dc.date.issued | 2022-02 | - |
dc.identifier.issn | 1759-7706 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/136513 | - |
dc.description.abstract | Background Studies on the application of targeted therapies for patients with non-small cell lung cancer (NSCLC) who harbor rare genetic mutations are ongoing. In the present study, we investigated the real-world data of NSCLC patients who harbor rare mutations. Methods We retrospectively analyzed patients with advanced or metastatic nonsquamous NSCLC aged >20 years with confirmed rare mutations (BRAF, ROS1, MET, RET, HER2, FGFR, and NTRK) from January 2015 to September 2020 at nine tertiary hospitals. In addition, we validated the lung cancer PCR panel kit in patients with confirmed mutations by NGS. Results Among 118 patients included, 88 received platinum-based chemotherapy as first-line chemotherapy. The progression-free survival of patients with BRAF, ERBB2, MET, RET, and ROS1 mutations was 10.9 months (95% confidence interval [CI]: 1.3-20.5), 5.3 months (95% CI: 3.0-7.5), 7.2 months (95% CI: 3.6-10.9), 11.4 months (95% CI: 9.2-13.6), and 10.0 months (95% CI: 3.7-16.4) respectively (p = 0.041). The median overall survival (OS) was not reached in patients with ROS1 mutations; however, in BRAF, ERBB2, MET, and RET mutant patients, median OS was 14.1 months (95% CI: 10.1-14.1), 34.5 months (95% CI: 13.2-36.9), 22.7 months (95% CI: 1.7-24.0), and 29.8 months (95% CI: 28.9-61.3), respectively (p = 0.006). Of the 27 tissue samples, 26 (96.3%) showed the same PCR panel kit result with NGS. Conclusions First-line platinum-based chemotherapy showed durable benefit in patients with advanced or metastatic nonsquamous NSCLC harboring rare genetic mutation other than EGFR or ALK. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | BRAF MUTATIONS | - |
dc.subject | EFFICACY | - |
dc.subject | PCR | - |
dc.subject | NGS | - |
dc.title | Multicenter real-world data of patients harboring rare mutations other than EGFR or ALK in advanced or metastatic non-small cell lung cancer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Sung Yong | - |
dc.identifier.doi | 10.1111/1759-7714.14266 | - |
dc.identifier.scopusid | 2-s2.0-85120821778 | - |
dc.identifier.wosid | 000728675600001 | - |
dc.identifier.bibliographicCitation | THORACIC CANCER, v.13, no.3, pp.380 - 385 | - |
dc.relation.isPartOf | THORACIC CANCER | - |
dc.citation.title | THORACIC CANCER | - |
dc.citation.volume | 13 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 380 | - |
dc.citation.endPage | 385 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.subject.keywordPlus | BRAF MUTATIONS | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | PCR | - |
dc.subject.keywordPlus | NGS | - |
dc.subject.keywordAuthor | chemotherapy | - |
dc.subject.keywordAuthor | non-small cell lung cancer | - |
dc.subject.keywordAuthor | oncogene | - |
dc.subject.keywordAuthor | platinum | - |
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