Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

OCT4-induced oligodendrocyte progenitor cells promote remyelination and ameliorate disease

Full metadata record
DC Field Value Language
dc.contributor.authorYun, Wonjin-
dc.contributor.authorChoi, Kyung-Ah-
dc.contributor.authorHwang, Insik-
dc.contributor.authorZheng, Jie-
dc.contributor.authorPark, Minji-
dc.contributor.authorHong, Wonjun-
dc.contributor.authorJang, Ah-Young-
dc.contributor.authorKim, Jeong Hee-
dc.contributor.authorChoi, Wonji-
dc.contributor.authorKim, Dae-Sung-
dc.contributor.authorKim, In Yong-
dc.contributor.authorKim, Yong Jun-
dc.contributor.authorLiu, Ying-
dc.contributor.authorYoon, Byung Sun-
dc.contributor.authorPark, Gyuman-
dc.contributor.authorSong, Gwonhwa-
dc.contributor.authorHong, Sunghoi-
dc.contributor.authorYou, Seungkwon-
dc.date.accessioned2022-02-22T17:41:55Z-
dc.date.available2022-02-22T17:41:55Z-
dc.date.created2022-02-11-
dc.date.issued2022-01-13-
dc.identifier.issn2057-3995-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/136525-
dc.description.abstractThe generation of human oligodendrocyte progenitor cells (OPCs) may be therapeutically valuable for human demyelinating diseases such as multiple sclerosis. Here, we report the direct reprogramming of human somatic cells into expandable induced OPCs (iOPCs) using a combination of OCT4 and a small molecule cocktail. This method enables generation of A2B5(+) (an early marker for OPCs) iOPCs within 2 weeks retaining the ability to differentiate into MBP-positive mature oligodendrocytes. RNA-seq analysis revealed that the transcriptome of O4(+) iOPCs was similar to that of O4(+) OPCs and ChIP-seq analysis revealed that putative OCT4-binding regions were detected in the regulatory elements of CNS development-related genes. Notably, engrafted iOPCs remyelinated the brains of adult shiverer mice and experimental autoimmune encephalomyelitis mice with MOG-induced 14 weeks after transplantation. In conclusion, our study may contribute to the development of therapeutic approaches for neurological disorders, as well as facilitate the understanding of the molecular mechanisms underlying glial development.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherNATURE PORTFOLIO-
dc.subjectEMBRYONIC STEM-CELLS-
dc.subjectTRANSCRIPTION FACTOR-
dc.subjectHUMAN FIBROBLASTS-
dc.subjectEFFICIENT GENERATION-
dc.subjectMULTIPLE-SCLEROSIS-
dc.subjectLINEAGE-
dc.subjectMOUSE-
dc.subjectMYELIN-
dc.subjectOCT4-
dc.subjectDIFFERENTIATION-
dc.titleOCT4-induced oligodendrocyte progenitor cells promote remyelination and ameliorate disease-
dc.typeArticle-
dc.contributor.affiliatedAuthorKim, Dae-Sung-
dc.contributor.affiliatedAuthorSong, Gwonhwa-
dc.contributor.affiliatedAuthorHong, Sunghoi-
dc.identifier.doi10.1038/s41536-021-00199-z-
dc.identifier.scopusid2-s2.0-85123115772-
dc.identifier.wosid000742367000001-
dc.identifier.bibliographicCitationNPJ REGENERATIVE MEDICINE, v.7, no.1-
dc.relation.isPartOfNPJ REGENERATIVE MEDICINE-
dc.citation.titleNPJ REGENERATIVE MEDICINE-
dc.citation.volume7-
dc.citation.number1-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaCell Biology-
dc.relation.journalResearchAreaEngineering-
dc.relation.journalWebOfScienceCategoryCell & Tissue Engineering-
dc.relation.journalWebOfScienceCategoryEngineering, Biomedical-
dc.subject.keywordPlusEMBRYONIC STEM-CELLS-
dc.subject.keywordPlusTRANSCRIPTION FACTOR-
dc.subject.keywordPlusHUMAN FIBROBLASTS-
dc.subject.keywordPlusEFFICIENT GENERATION-
dc.subject.keywordPlusMULTIPLE-SCLEROSIS-
dc.subject.keywordPlusLINEAGE-
dc.subject.keywordPlusMOUSE-
dc.subject.keywordPlusMYELIN-
dc.subject.keywordPlusOCT4-
dc.subject.keywordPlusDIFFERENTIATION-
Files in This Item
There are no files associated with this item.
Appears in
Collections
Graduate School > Department of Biotechnology > 1. Journal Articles
College of Health Sciences > School of Biosystems and Biomedical Sciences > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Song, Gwon hwa photo

Song, Gwon hwa
융합생명공학과
Read more

Altmetrics

Total Views & Downloads

BROWSE