Performance evaluation of the Anysis-200 platelet function analyzer in cardiac patients
DC Field | Value | Language |
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dc.contributor.author | Park, Seong Jun | - |
dc.contributor.author | Yoon, Jung | - |
dc.contributor.author | Seo, Hong Seog | - |
dc.contributor.author | Lim, Chae Seung | - |
dc.date.accessioned | 2022-02-23T05:40:39Z | - |
dc.date.available | 2022-02-23T05:40:39Z | - |
dc.date.created | 2022-02-21 | - |
dc.date.issued | 2022 | - |
dc.identifier.issn | 1386-0291 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/136585 | - |
dc.description.abstract | BACKGROUND: Platelet function analysis is crucial in assessing the hemostatic status to evaluate congenital and acquired platelet function defects. The Anysis-200 analyzer is a new automated lab-on-a-chip-based platelet function analyzer. OBJECTIVE: We aimed to evaluate a new platelet function analyzing system, the Anysis-200 in comparison to the Platelet Function Analyzer (PFA)-200 in cardiac patients. METHODS: Citrated blood was collected from 174 patients who visited the Department of Cardiology. The Anysis-200 consists of two kits, the microchips with collagen and epinephrine-coated membrane (C/EPI) or adenosine diphosphate-coated membrane (C/ADP). Platelet clogging in the Anysis-200 is measured by the blood migration distance obtained by a camera, which is compatible with the closure time in the PFA-200. We performed Anysis-200 and PFA-200 analyzers simultaneously and compared the results. RESULTS: The sensitivity and specificity of the Anysis-200 C/EPI kit in comparison to the PFA-200 C/EPI kit were 63.41% and 91.43%, respectively. Regarding the C/ADP kit, the sensitivity and specificity of the Anysis-200 were 58.97% and 74.29%, respectively. The agreement rate between the Anysis-200 and PFA-200 for C/EPI was 83.35% and 70.14% for C/ADP. CONCLUSIONS: The Anysis-200, which applies a novel method to detect platelet clogging, has shown moderate to fair agreement with the PFA-200. This test is potentially useful for screening cardiac patients with an abnormal platelet function. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | IOS PRESS | - |
dc.subject | CLINICAL UTILITY | - |
dc.subject | AGGREGATION | - |
dc.title | Performance evaluation of the Anysis-200 platelet function analyzer in cardiac patients | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Seo, Hong Seog | - |
dc.identifier.doi | 10.3233/CH-190801 | - |
dc.identifier.scopusid | 2-s2.0-85094604816 | - |
dc.identifier.wosid | 000752431800003 | - |
dc.identifier.bibliographicCitation | CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, v.80, no.1, pp.17 - 24 | - |
dc.relation.isPartOf | CLINICAL HEMORHEOLOGY AND MICROCIRCULATION | - |
dc.citation.title | CLINICAL HEMORHEOLOGY AND MICROCIRCULATION | - |
dc.citation.volume | 80 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 17 | - |
dc.citation.endPage | 24 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.relation.journalWebOfScienceCategory | Peripheral Vascular Disease | - |
dc.subject.keywordPlus | CLINICAL UTILITY | - |
dc.subject.keywordPlus | AGGREGATION | - |
dc.subject.keywordAuthor | Platelet function | - |
dc.subject.keywordAuthor | Anysis-200 analyzer | - |
dc.subject.keywordAuthor | PFA-200 analyzer | - |
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