Regulation of autophagy by protein methylation and acetylation in cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeon, Minsol | - |
dc.contributor.author | Park, Jisu | - |
dc.contributor.author | Yang, Eunbi | - |
dc.contributor.author | Baek, Hee-ji | - |
dc.contributor.author | Kim, Hyunkyung | - |
dc.date.accessioned | 2022-02-23T19:41:04Z | - |
dc.date.available | 2022-02-23T19:41:04Z | - |
dc.date.created | 2022-02-11 | - |
dc.date.issued | 2022-01 | - |
dc.identifier.issn | 0021-9541 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/136657 | - |
dc.description.abstract | Autophagy is a highly conserved mechanism responsible for cellular homeostasis and integrity in a variety of physiological conditions. Materials targeted for degradation are directed to autophagosomes and autolysosomes, where they are broken down into their base components. Aberrant regulation of autophagy is significantly associated with various cancers and neurodegenerative diseases. Recently, accumulating evidence has revealed that the coordinated regulation of histone and non-histone protein modification is associated with autophagy. In this review, we highlight the recent progress that has been made in elucidating the molecular basis of protein methylation and acetylation associated with autophagy at the transcriptional and posttranslational levels. Furthermore, we discuss the importance of describing causality between protein methylation/acetylation and autophagy regulation as compelling therapeutic opportunities in cancer pathogenesis and progression. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | H3 LYSINE 56 | - |
dc.subject | HISTONE H3 | - |
dc.subject | TRANSCRIPTIONAL REGULATION | - |
dc.subject | METHYLTRANSFERASE EZH2 | - |
dc.subject | SELECTIVE DEGRADATION | - |
dc.subject | EPIGENETIC REGULATION | - |
dc.subject | INHIBITS AUTOPHAGY | - |
dc.subject | PROTEOMIC ANALYSIS | - |
dc.subject | EARLY STEPS | - |
dc.subject | DEACETYLATION | - |
dc.title | Regulation of autophagy by protein methylation and acetylation in cancer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hyunkyung | - |
dc.identifier.doi | 10.1002/jcp.30502 | - |
dc.identifier.scopusid | 2-s2.0-85109392252 | - |
dc.identifier.wosid | 000670731400001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CELLULAR PHYSIOLOGY, v.237, no.1, pp.13 - 28 | - |
dc.relation.isPartOf | JOURNAL OF CELLULAR PHYSIOLOGY | - |
dc.citation.title | JOURNAL OF CELLULAR PHYSIOLOGY | - |
dc.citation.volume | 237 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 13 | - |
dc.citation.endPage | 28 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Physiology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Physiology | - |
dc.subject.keywordPlus | H3 LYSINE 56 | - |
dc.subject.keywordPlus | HISTONE H3 | - |
dc.subject.keywordPlus | TRANSCRIPTIONAL REGULATION | - |
dc.subject.keywordPlus | METHYLTRANSFERASE EZH2 | - |
dc.subject.keywordPlus | SELECTIVE DEGRADATION | - |
dc.subject.keywordPlus | EPIGENETIC REGULATION | - |
dc.subject.keywordPlus | INHIBITS AUTOPHAGY | - |
dc.subject.keywordPlus | PROTEOMIC ANALYSIS | - |
dc.subject.keywordPlus | EARLY STEPS | - |
dc.subject.keywordPlus | DEACETYLATION | - |
dc.subject.keywordAuthor | autophagy | - |
dc.subject.keywordAuthor | cancer | - |
dc.subject.keywordAuthor | protein acetylation | - |
dc.subject.keywordAuthor | protein methylation | - |
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