Induction of Peptide-specific CTL Activity and Inhibition of Tumor Growth Following Immunization with Nanoparticles Coated with Tumor Peptide-MHC-I Complexes
DC Field | Value | Language |
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dc.contributor.author | Kim, Sang-Hyun | - |
dc.contributor.author | Park, Ha-Eun | - |
dc.contributor.author | Jeong, Seong-Un | - |
dc.contributor.author | Moon, Jun-Hyeok | - |
dc.contributor.author | Lee, Young-Ran | - |
dc.contributor.author | Kim, Jeong-Ki | - |
dc.contributor.author | Kong, Hyunseok | - |
dc.contributor.author | Park, Chan-Su | - |
dc.contributor.author | Lee, Chong-Kil | - |
dc.date.accessioned | 2022-02-23T21:40:42Z | - |
dc.date.available | 2022-02-23T21:40:42Z | - |
dc.date.created | 2022-02-15 | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 1598-2629 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/136666 | - |
dc.description.abstract | Tumor peptides associated with MHC class I molecules or their synthetic variants have attracted great attention for their potential use as vaccines to induce tumor-specific CTLs. However, the outcome of clinical trials of peptide-based tumor vaccines has been disappointing. There are various reasons for this lack of success, such as difficulties in delivering the peptides specifically to professional Ag-presenting cells, short peptide half-life in vivo, and limited peptide immunogenicity. We report here a novel peptide vaccination strategy that efficiently induces peptide-specific CTLs. Nanoparticles (NPs) were fabricated from a biodegradable polymer, poly(D,L-lactic-co-glycolic acid), attached to H-2K(b) molecules, and then the natural peptide epitopes associated with the H-2K(b) molecules were exchanged with a model tumor peptide, SIINFEKL (OVA(257-268)). These NPs were efficiently phagocytosed by immature dendritic cells (DCs), inducing DC maturation and activation. In addition, the DCs that phagocytosed SIINFEKL-pulsed NPs potently activated SIINFEKL-H-2K(b) complex-specific CD8(+) T cells via cross-presentation of SIINFEKL. In vivo studies showed that intravenous administration of SIINFEKL-pulsed NPs effectively generated SIINFEKL-specific CD8(+) T cells in both normal and tumor-bearing mice. Furthermore, intravenous administration of SIINFEKL-pulsed NPs into EG7.OVA tumor-bearing mice almost completely inhibited the tumor growth. These results demonstrate that vaccination with polymeric NPs coated with tumor peptide-MHC-I complexes is a novel strategy for efficient induction of tumor-specific CTLs. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREA ASSOC IMMUNOLOGISTS | - |
dc.subject | DENDRITIC CELLS | - |
dc.subject | CANCER | - |
dc.subject | VACCINES | - |
dc.subject | FUTURE | - |
dc.title | Induction of Peptide-specific CTL Activity and Inhibition of Tumor Growth Following Immunization with Nanoparticles Coated with Tumor Peptide-MHC-I Complexes | - |
dc.title.alternative | Induction of Peptide-specific CTL Activity and Inhibition of Tumor Growth Following Immunization with Nanoparticles Coated with Tumor Peptide-MHC-I Complexes | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jeong-Ki | - |
dc.identifier.doi | 10.4110/in.2021.21.e44 | - |
dc.identifier.scopusid | 2-s2.0-85128737329 | - |
dc.identifier.wosid | 000748621600005 | - |
dc.identifier.bibliographicCitation | IMMUNE NETWORK, v.21, no.6, pp.1 - 15 | - |
dc.relation.isPartOf | IMMUNE NETWORK | - |
dc.citation.title | IMMUNE NETWORK | - |
dc.citation.volume | 21 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 15 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002797744 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | VACCINES | - |
dc.subject.keywordPlus | FUTURE | - |
dc.subject.keywordAuthor | Polymeric nanoparticle | - |
dc.subject.keywordAuthor | Tumor peptide | - |
dc.subject.keywordAuthor | Peptide-MHC-I complex | - |
dc.subject.keywordAuthor | Tumor vaccine | - |
dc.subject.keywordAuthor | Cytotoxic T lymphocyte | - |
dc.subject.keywordAuthor | Anti-tumor activity | - |
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