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Reproductive toxicity of folpet through deregulation of calcium homeostasis in porcine trophectoderm and luminal epithelial cells during early pregnancy

Authors
Park, SunwooYun, Bo HyunBae, HyocheolLim, WhasunSong, Gwonhwa
Issue Date
11월-2021
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Keywords
Folpet; Trophectoderm; Luminal epithelial cell; Calcium; Migration
Citation
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, v.179
Indexed
SCIE
SCOPUS
Journal Title
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
Volume
179
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/136679
DOI
10.1016/j.pestbp.2021.104974
ISSN
0048-3575
Abstract
Folpet, a fungicide, is utilized even in cosmetics and pharmaceuticals. The LD50 of folpet in mammals, birds, and fish is relatively high. Recently, several negative effects of folpet on the respiratory system and cornea have been reported. However, there is no study on the negative effects of folpet on maternal-fetus interactions. In the present study, we used porcine trophectoderm (pTr) cells and porcine luminal epithelial (pLE) cells to investigate the toxic effects of folpet during implantation. Folpet treatment decreased cell proliferation and promoted apoptosis with cell cycle arrest. In addition, the ERK, JNK, and AKT signal pathways were activated by folpet treatment. Folpet treatment induced calcium overload in pTr and pLE cells mediating antimigratory and antiadhesive effects in both cell lines. Co-treatment with calcium chelates decreased the anti-implantation effect of folpet. Overall, our results demonstrated potential reproductive toxicity of folpet in pig.
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