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Recent Advances in Exosome-Based Drug Delivery for Cancer Therapy

Authors
Kim, HyosukJang, HochungCho, HaeunChoi, JiwonHwang, Kwang YeonChoi, YeonhoKim, Sun HwaYang, Yoosoo
Issue Date
9월-2021
Publisher
MDPI
Keywords
cancer therapy; drug delivery system; exosome; exosome engineering
Citation
CANCERS, v.13, no.17
Indexed
SCIE
SCOPUS
Journal Title
CANCERS
Volume
13
Number
17
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/136713
DOI
10.3390/cancers13174435
ISSN
2072-6694
Abstract
Simple Summary Exosomes derived from various sources can deliver therapeutic agents such as small molecule drugs, nucleic acids, and proteins to cancer cells by passive or active targeting. These exosomes can encapsulate drugs inside the exosomes, extending drug half-life and increasing drug release stability. In addition, exosomes are highly biocompatible due to their endogenous origin and can be used as nanocarriers for tissue-specific targeted delivery. This review discusses recent advances in exosome-based drug delivery for cancer therapy. Exosomes are a class of extracellular vesicles, with a size of about 100 nm, secreted by most cells and carrying various bioactive molecules such as nucleic acids, proteins, and lipids, and reflect the biological status of parent cells. Exosomes have natural advantages such as high biocompatibility and low immunogenicity for efficient delivery of therapeutic agents such as chemotherapeutic drugs, nucleic acids, and proteins. In this review, we introduce the latest explorations of exosome-based drug delivery systems for cancer therapy, with particular focus on the targeted delivery of various types of cargoes.
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