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PTP1B Inhibitory Secondary Metabolites from an Antarctic Fungal Strain Acremonium sp. SF-7394

Authors
Kim, Hye JinLi, Xiao-JunKim, Dong-CheolKim, Tai KyoungSohn, Jae HakKwon, HaeunLee, DonghoKim, Youn-ChulYim, Joung HanOh, Hyuncheol
Issue Date
9월-2021
Publisher
MDPI
Keywords
Acremonium sp; Antarctic fungal metabolites; PTP1B; terpenoids
Citation
MOLECULES, v.26, no.18
Indexed
SCIE
SCOPUS
Journal Title
MOLECULES
Volume
26
Number
18
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/136728
DOI
10.3390/molecules26185505
ISSN
1420-3049
Abstract
Chemical investigation of the Antarctic lichen-derived fungal strain Acremonium sp. SF-7394 yielded a new amphilectane-type diterpene, acrepseudoterin (1), and a new acorane-type sesquiterpene glycoside, isocordycepoloside A (2). In addition, three known fungal metabolites, (-)-ternatin (3), [D-Leu]-ternatin (4), and pseurotin A (5), were isolated from the EtOAc extract of the fungal strain. Their structures were mainly elucidated by analyzing their NMR and MS data. The absolute configuration of 1 was proposed by electronic circular dichroism calculations, and the absolute configuration of the sugar unit in 2 was determined by a chemical method. The inhibitory effects of the isolated compounds on protein tyrosine phosphatase 1B (PTP1B) were evaluated by enzymatic assays; results indicated that acrepseudoterin (1) and [D-Leu]-ternatin (4) dose-dependently inhibited the enzyme activity with IC50 values of 22.8 +/- 1.1 mu M and 14.8 +/- 0.3 mu M, respectively. Moreover, compound 1 was identified as a competitive inhibitor of PTP1B.
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