Establishment of an Experimental System for Intraperitoneal Chemotherapy in a Rat Model
DC Field | Value | Language |
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dc.contributor.author | Park, Sunwoo | - |
dc.contributor.author | Park, Soo Jin | - |
dc.contributor.author | Lee, Hee Su | - |
dc.contributor.author | Ham, Jiyeon | - |
dc.contributor.author | Lee, Eun Ji | - |
dc.contributor.author | Kim, Junsik | - |
dc.contributor.author | Ryu, Soomin | - |
dc.contributor.author | Seol, Aeran | - |
dc.contributor.author | Lim, Whasun | - |
dc.contributor.author | Lee, Jung Chan | - |
dc.contributor.author | Song, Gwonhwa | - |
dc.contributor.author | Kim, Hee seung | - |
dc.date.accessioned | 2022-02-24T11:41:20Z | - |
dc.date.available | 2022-02-24T11:41:20Z | - |
dc.date.created | 2022-02-07 | - |
dc.date.issued | 2021-09 | - |
dc.identifier.issn | 0258-851X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/136738 | - |
dc.description.abstract | Aim: To establish an experimental system for comparing different methods of intraperitoneal chemotherapy in a rat model. Materials and Methods: We used six-week-old Sprague-Dawley rats, and created an early postoperative intraperitoneal chemotherapy (EPIC) system using 18-gauge syringes and evacuators, and a hyperthermic intraperitoneal chemotherapy (HIPEC) system using two peristaltic pumps which controlled the flow rate and temperature. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) was achieved using a nozzle for dispersing aerosols at a flow rate up to 41.5 ml/min. The distribution and intensity of 0.2% trypan blue dye was compared among three methods. Results: The distribution was limited and the intensity was weak after EPIC, and the dye stained moderately in gravity-dependent regions after HIPEC. On the other hand, the distribution was the most comprehensive, and the intensity was the greatest after PIPAC. Conclusion: This experimental system in a rat model may reflect the comparative effect among EPIC, HIPEC and PIPAC in humans. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | INT INST ANTICANCER RESEARCH | - |
dc.subject | PERITONEAL CARCINOMATOSIS | - |
dc.subject | AEROSOL CHEMOTHERAPY | - |
dc.subject | OVARIAN-CANCER | - |
dc.subject | CYTOREDUCTIVE SURGERY | - |
dc.subject | TISSUE DISTRIBUTION | - |
dc.subject | PHARMACOKINETICS | - |
dc.subject | HYPERTHERMIA | - |
dc.subject | CHEMOPERFUSION | - |
dc.subject | DOXORUBICIN | - |
dc.subject | PACLITAXEL | - |
dc.title | Establishment of an Experimental System for Intraperitoneal Chemotherapy in a Rat Model | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Gwonhwa | - |
dc.identifier.doi | 10.21873/invivo.12554 | - |
dc.identifier.scopusid | 2-s2.0-85113824455 | - |
dc.identifier.wosid | 000686259500013 | - |
dc.identifier.bibliographicCitation | IN VIVO, v.35, no.5, pp.2703 - 2710 | - |
dc.relation.isPartOf | IN VIVO | - |
dc.citation.title | IN VIVO | - |
dc.citation.volume | 35 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 2703 | - |
dc.citation.endPage | 2710 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | AEROSOL CHEMOTHERAPY | - |
dc.subject.keywordPlus | CHEMOPERFUSION | - |
dc.subject.keywordPlus | CYTOREDUCTIVE SURGERY | - |
dc.subject.keywordPlus | DOXORUBICIN | - |
dc.subject.keywordPlus | HYPERTHERMIA | - |
dc.subject.keywordPlus | OVARIAN-CANCER | - |
dc.subject.keywordPlus | PACLITAXEL | - |
dc.subject.keywordPlus | PERITONEAL CARCINOMATOSIS | - |
dc.subject.keywordPlus | PHARMACOKINETICS | - |
dc.subject.keywordPlus | TISSUE DISTRIBUTION | - |
dc.subject.keywordAuthor | Experimental system | - |
dc.subject.keywordAuthor | intraperitoneal chemotherapy | - |
dc.subject.keywordAuthor | rat | - |
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