Development of Carbazole Derivatives Compounds against Candida albicans: Candidates to Prevent Hyphal Formation via the Ras1-MAPK Pathway
DC Field | Value | Language |
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dc.contributor.author | Park, Young-Kwang | - |
dc.contributor.author | Shin, Jisoo | - |
dc.contributor.author | Lee, Hee-Yoon | - |
dc.contributor.author | Kim, Hag-Dong | - |
dc.contributor.author | Kim, Joon | - |
dc.date.accessioned | 2022-02-24T15:41:09Z | - |
dc.date.available | 2022-02-24T15:41:09Z | - |
dc.date.created | 2022-02-07 | - |
dc.date.issued | 2021-09 | - |
dc.identifier.issn | 2309-608X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/136757 | - |
dc.description.abstract | Morphogenesis contributes to the virulence of the opportunistic human fungal pathogen Candida albicans. Ras1-MAPK pathways play a critical role in the virulence of C. albicans by regulating cell growth, morphogenesis, and biofilm formation. Ume6 acts as a transcription factor, and Nrg1 is a transcriptional repressor for the expression of hyphal-specific genes in morphogenesis. Azoles or echinocandin drugs have been extensively prescribed for C. albicans infections, which has led to the development of drug-resistant strains. Therefore, it is necessary to develop new molecules to effectively treat fungal infections. Here, we showed that Molecule B and Molecule C, which contained a carbazole structure, attenuated the pathogenicity of C. albicans through inhibition of the Ras1/MAPK pathway. We found that Molecule B and Molecule C inhibit morphogenesis through repressing protein and RNA levels of Ras/MAPK-related genes, including UME6 and NRG1. Furthermore, we determined the antifungal effects of Molecule B and Molecule C in vivo using a candidiasis murine model. We anticipate our findings are that Molecule B and Molecule C, which inhibits the Ras1/MAPK pathway, are promising compounds for the development of new antifungal agents for the treatment of systemic candidiasis and possibly for other fungal diseases. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | RIBOSOMAL-PROTEIN | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | PIVOTAL ROLE | - |
dc.subject | MORPHOGENESIS | - |
dc.subject | GROWTH | - |
dc.subject | REGULATOR | - |
dc.subject | VIRULENCE | - |
dc.subject | PLAYS | - |
dc.subject | UME6 | - |
dc.subject | NRG1 | - |
dc.title | Development of Carbazole Derivatives Compounds against Candida albicans: Candidates to Prevent Hyphal Formation via the Ras1-MAPK Pathway | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Joon | - |
dc.identifier.doi | 10.3390/jof7090688 | - |
dc.identifier.scopusid | 2-s2.0-85113969524 | - |
dc.identifier.wosid | 000699807600001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF FUNGI, v.7, no.9 | - |
dc.relation.isPartOf | JOURNAL OF FUNGI | - |
dc.citation.title | JOURNAL OF FUNGI | - |
dc.citation.volume | 7 | - |
dc.citation.number | 9 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalResearchArea | Mycology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Mycology | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | MORPHOGENESIS | - |
dc.subject.keywordPlus | NRG1 | - |
dc.subject.keywordPlus | PIVOTAL ROLE | - |
dc.subject.keywordPlus | PLAYS | - |
dc.subject.keywordPlus | REGULATOR | - |
dc.subject.keywordPlus | RIBOSOMAL-PROTEIN | - |
dc.subject.keywordPlus | UME6 | - |
dc.subject.keywordPlus | VIRULENCE | - |
dc.subject.keywordAuthor | Candida albicans | - |
dc.subject.keywordAuthor | MAPK pathway | - |
dc.subject.keywordAuthor | Ras1 | - |
dc.subject.keywordAuthor | biofilm formation | - |
dc.subject.keywordAuthor | candidiasis | - |
dc.subject.keywordAuthor | drug development | - |
dc.subject.keywordAuthor | drug resistance | - |
dc.subject.keywordAuthor | fungi | - |
dc.subject.keywordAuthor | morphogenesis | - |
dc.subject.keywordAuthor | pathogenicity | - |
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