Early enteral nutrition and factors related to in-hospital mortality in people on extracorporeal membrane oxygenation

Abstract

Objectives: There are concerns about adverse events related to early enteral nutrition (EN) in people receiving extracorporeal membrane oxygenation (ECMO). This was a retrospective study evaluating. This nutritional support of people receiving ECMO, factors that may confer benefits in outcomes. Methods: 60 adults on ECMO who survived for more than 48 h were enrolled in the study. We evaluated energy and protein intake and the associations of the timing, adequacy, and route of nutrition with in-hospital mortality. Results: Thirty-three participants (55%) were successfully weaned off ECMO, and 30 (50%) survived. EN initiated on day 2 of ECMO (interquartile range, 1-3), and the mean energy intake on day 7 of ECMO 94.1% +/- 41.8% of the energy requirement. Although early EN significantly decreased in-hospital mortality (hazard ratio, 0.413; 95% confidence interval, 0.174-0.984; P = 0.046), neither adequate energy intake ard ratio, 0.982; 95% confidence interval, 0.292-3.301; P = 0.977) nor EN-dominant nutritional support ard ratio, 0.394; 95% confidence interval, 0.138-1.128; P = 0.083) in the first week influenced survival. Conclusions: Although adequate nutritional support and EN-dominant nutritional support were not associated with changes in outcome, early EN was associated with reduced in-hospital mortality. Therefore, when EN is not the dominant route of nutritional support, early EN may be recommended for better comes in people on ECMO. (c) 2021 Elsevier Inc. All rights reserved.