Efficacy of Triptorelin 3-Month Depot Compared to 1-Month Depot for the Treatment of Korean Girls with Central Precocious Puberty in Single Tertiary Center
DC Field | Value | Language |
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dc.contributor.author | Chung, Lindsey Yoojin | - |
dc.contributor.author | Kang, Eungu | - |
dc.contributor.author | Nam, Hyo-Kyoung | - |
dc.contributor.author | Rhie, Young-Jun | - |
dc.contributor.author | Lee, Kee-Hyoung | - |
dc.date.accessioned | 2022-02-24T23:41:10Z | - |
dc.date.available | 2022-02-24T23:41:10Z | - |
dc.date.created | 2022-02-07 | - |
dc.date.issued | 2021-08-30 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/136797 | - |
dc.description.abstract | Background: Triptorelin depot is largely used to treat central precocious puberty (CPP) in children, and a 3-month depot has been introduced. However, data about the 3-month gonadotropin-releasing hormone use for treatment of CPP in Korean girls are not available. This study was conducted to compare the efficacy of a triptorelin 11.25 mg 3-month depot with that of a 3.75 mg 1-month depot in suppressing pubertal development for the treatment of CPP. Methods: A retrospective study, including 106 girls with CPP treated with triptorelin, was conducted. Fifty patients were treated with a triptorelin 3-month depot, and 56 were treated with a triptorelin 1-month depot. Serum luteinizing hormone (LH), follicle-stimulating hormone, and estradiol levels were analysed every 6 months after the visit. The height and bone age of each patient was evaluated at the beginning of treatment, after 6 months, and one year after therapy. Results: The baseline characteristics of the girls treated with a 3-month depot were similar to those of the girls treated with a 1-month depot. A suppressed levels of LH to the triptorelin injection (serum LH < 2.5 IU/L) at 6 months was seen in 90.0% and 98.2% of the girls treated with the 3-month and 1-month depots, respectively (P = 0.160). After 1 year of treatment, a suppressed levels of LH was seen in 93.5% and 100% of the girls treated with the 3-month and 1-month depots, respectively (P = 0.226). Height velocity showed no significant difference between the two groups. Degree of bone age advancement decreased from 1.22 +/- 0.07 and 1.22 +/- 0.08 years at baseline (P = 0.914) to 1.16 +/- 0.07 and 1.17 +/- 0.08 in the girls treated with the 3-month and 1-month depots after 1 year, respectively (P = 0.481). Conclusion: This study showed that the efficacy of long-acting triptorelin 3-month was comparable to 1-month depot regarding hormonal suppression and inhibition of bone maturation. The triptorelin 11.25 mg 3-month depot is an effective treatment for girls with CPP. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | - |
dc.subject | GNRH ANALOG | - |
dc.subject | 11.25 MG | - |
dc.subject | LEUPROLIDE | - |
dc.subject | CHILDREN | - |
dc.subject | THERAPY | - |
dc.subject | SAMPLE | - |
dc.subject | TRIAL | - |
dc.subject | LH | - |
dc.title | Efficacy of Triptorelin 3-Month Depot Compared to 1-Month Depot for the Treatment of Korean Girls with Central Precocious Puberty in Single Tertiary Center | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Nam, Hyo-Kyoung | - |
dc.contributor.affiliatedAuthor | Rhie, Young-Jun | - |
dc.contributor.affiliatedAuthor | Lee, Kee-Hyoung | - |
dc.identifier.doi | 10.3346/jkms.2021.36.e219 | - |
dc.identifier.scopusid | 2-s2.0-85113317699 | - |
dc.identifier.wosid | 000692580400004 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, v.36, no.34, pp.1 - 9 | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.title | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.volume | 36 | - |
dc.citation.number | 34 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 9 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002746711 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | 11.25 MG | - |
dc.subject.keywordPlus | CHILDREN | - |
dc.subject.keywordPlus | GNRH ANALOG | - |
dc.subject.keywordPlus | LEUPROLIDE | - |
dc.subject.keywordPlus | LH | - |
dc.subject.keywordPlus | SAMPLE | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | TRIAL | - |
dc.subject.keywordAuthor | Central Precocious Puberty | - |
dc.subject.keywordAuthor | Gonadotropin-releasing Hormone Analogue | - |
dc.subject.keywordAuthor | Korea | - |
dc.subject.keywordAuthor | Triptorelin Pamoate | - |
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