Microbial Enzymatic Synthesis of Amikacin Analogs With Antibacterial Activity Against Multidrug-Resistant Pathogens
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ban, Yeon Hee | - |
dc.contributor.author | Song, Myoung Chong | - |
dc.contributor.author | Jeong, Joong Ho | - |
dc.contributor.author | Kwun, Min Seok | - |
dc.contributor.author | Kim, Chang Rae | - |
dc.contributor.author | Ryu, Hwi So | - |
dc.contributor.author | Kim, Eunji | - |
dc.contributor.author | Park, Je Won | - |
dc.contributor.author | Lee, Dong Gun | - |
dc.contributor.author | Yoon, Yeo Joon | - |
dc.date.accessioned | 2022-02-25T00:41:14Z | - |
dc.date.available | 2022-02-25T00:41:14Z | - |
dc.date.created | 2022-02-07 | - |
dc.date.issued | 2021-08-27 | - |
dc.identifier.issn | 1664-302X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/136802 | - |
dc.description.abstract | With the constant emergence of multidrug-resistant gram-negative bacteria, interest in the development of new aminoglycoside (AG) antibiotics for clinical use has increased. The regioselective modification of AG scaffolds could be an efficient approach for the development of new antibiotics with improved therapeutic potency. We enzymatically synthesized three amikacin analogs containing structural modifications in the amino groups and evaluated their antibacterial activity and cytotoxicity. Among them, 6 '-N-acyl-3('')-N-methylated analogs showed improved antibacterial activity against the multidrug-resistant gram-negative bacteria tested, while exhibiting reduced in vitro nephrotoxicity compared to amikacin. This study demonstrated that the modifications of the 6 '-amino group as well as the 3('')-amino group have noteworthy advantages for circumventing the AG-resistance mechanism. The regiospecific enzymatic modification could be exploited to develop novel antibacterial agents with improved pharmacological potential. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.subject | AMINOGLYCOSIDE ANTIBIOTICS | - |
dc.subject | BIOSYNTHESIS | - |
dc.subject | KANAMYCIN | - |
dc.subject | TOXICITY | - |
dc.subject | SIDE | - |
dc.title | Microbial Enzymatic Synthesis of Amikacin Analogs With Antibacterial Activity Against Multidrug-Resistant Pathogens | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Je Won | - |
dc.identifier.doi | 10.3389/fmicb.2021.725916 | - |
dc.identifier.scopusid | 2-s2.0-85114730772 | - |
dc.identifier.wosid | 000698801500001 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN MICROBIOLOGY, v.12 | - |
dc.relation.isPartOf | FRONTIERS IN MICROBIOLOGY | - |
dc.citation.title | FRONTIERS IN MICROBIOLOGY | - |
dc.citation.volume | 12 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.subject.keywordPlus | AMINOGLYCOSIDE ANTIBIOTICS | - |
dc.subject.keywordPlus | BIOSYNTHESIS | - |
dc.subject.keywordPlus | KANAMYCIN | - |
dc.subject.keywordPlus | SIDE | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordAuthor | amikacin analogs | - |
dc.subject.keywordAuthor | antibacterial activity | - |
dc.subject.keywordAuthor | cytotoxicity | - |
dc.subject.keywordAuthor | microbial enzymatic synthesis | - |
dc.subject.keywordAuthor | multidrug-resistant pathogens | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.