Mesenchymal stem cells for enhancing biological healing after meniscal injuries
DC Field | Value | Language |
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dc.contributor.author | Rhim, Hye Chang | - |
dc.contributor.author | Jeon, Ok Hee | - |
dc.contributor.author | Han, Seung-Beom | - |
dc.contributor.author | Bae, Ji Hoon | - |
dc.contributor.author | Suh, Dong Won | - |
dc.contributor.author | Jang, Ki-Mo | - |
dc.date.accessioned | 2022-02-25T00:41:33Z | - |
dc.date.available | 2022-02-25T00:41:33Z | - |
dc.date.created | 2022-02-07 | - |
dc.date.issued | 2021-08-26 | - |
dc.identifier.issn | 1948-0210 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/136803 | - |
dc.description.abstract | The meniscus is a semilunar fibrocartilage structure that plays important roles in maintaining normal knee biomechanics and function. The roles of the meniscus, including load distribution, force transmission, shock absorption, joint stability, lubrication, and proprioception, have been well established. Injury to the meniscus can disrupt overall joint stability and cause various symptoms including pain, swelling, giving-way, and locking. Unless treated properly, it can lead to early degeneration of the knee joint. Because meniscal injuries remain a significant challenge due to its low intrinsic healing potential, most notably in avascular and aneural inner two-thirds of the area, more efficient repair methods are needed. Mesenchymal stem cells (MSCs) have been investigated for their therapeutic potential in vitro and in vivo. Thus far, the application of MSCs, including bone marrow-derived, synovium-derived, and adipose-derived MSCs, has shown promising results in preclinical studies in different animal models. These preclinical studies could be categorized into intra-articular injection and tissue-engineered construct application according to delivery method. Despite promising results in preclinical studies, there is still a lack of clinical evidence. This review describes the basic knowledge, current treatment, and recent studies regarding the application of MSCs in treating meniscal injuries. Future directions for MSC-based approaches to enhance meniscal healing are suggested. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | BAISHIDENG PUBLISHING GROUP INC | - |
dc.subject | ARTHROSCOPIC PARTIAL MENISCECTOMY | - |
dc.subject | HUMAN ADIPOSE-TISSUE | - |
dc.subject | BONE-MARROW | - |
dc.subject | INTRAARTICULAR INJECTION | - |
dc.subject | HUMAN KNEE | - |
dc.subject | GROWTH-FACTORS | - |
dc.subject | ARTICULAR-CARTILAGE | - |
dc.subject | MR ARTHROGRAPHY | - |
dc.subject | AVASCULAR ZONE | - |
dc.subject | BASIC SCIENCE | - |
dc.title | Mesenchymal stem cells for enhancing biological healing after meniscal injuries | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jeon, Ok Hee | - |
dc.contributor.affiliatedAuthor | Jang, Ki-Mo | - |
dc.identifier.doi | 10.4252/wjsc.v13.i8.1005 | - |
dc.identifier.scopusid | 2-s2.0-85118972514 | - |
dc.identifier.wosid | 000697282600003 | - |
dc.identifier.bibliographicCitation | WORLD JOURNAL OF STEM CELLS, v.13, no.8, pp.1005 - 1029 | - |
dc.relation.isPartOf | WORLD JOURNAL OF STEM CELLS | - |
dc.citation.title | WORLD JOURNAL OF STEM CELLS | - |
dc.citation.volume | 13 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1005 | - |
dc.citation.endPage | 1029 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell & Tissue Engineering | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | ARTHROSCOPIC PARTIAL MENISCECTOMY | - |
dc.subject.keywordPlus | ARTICULAR-CARTILAGE | - |
dc.subject.keywordPlus | AVASCULAR ZONE | - |
dc.subject.keywordPlus | BASIC SCIENCE | - |
dc.subject.keywordPlus | BONE-MARROW | - |
dc.subject.keywordPlus | GROWTH-FACTORS | - |
dc.subject.keywordPlus | HUMAN ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | HUMAN KNEE | - |
dc.subject.keywordPlus | INTRAARTICULAR INJECTION | - |
dc.subject.keywordPlus | MR ARTHROGRAPHY | - |
dc.subject.keywordAuthor | Cell-based treatment | - |
dc.subject.keywordAuthor | Meniscus | - |
dc.subject.keywordAuthor | Meniscus healing | - |
dc.subject.keywordAuthor | Mesenchymal stem cell | - |
dc.subject.keywordAuthor | Tissue engineering | - |
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