Arsenene-mediated multiple independently targeted reactive oxygen species burst for cancer therapy
DC Field | Value | Language |
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dc.contributor.author | Kong, Na | - |
dc.contributor.author | Zhang, Hanjie | - |
dc.contributor.author | Feng, Chan | - |
dc.contributor.author | Liu, Chuang | - |
dc.contributor.author | Xiao, Yufen | - |
dc.contributor.author | Zhang, Xingcai | - |
dc.contributor.author | Mei, Lin | - |
dc.contributor.author | Kim, Jong Seung | - |
dc.contributor.author | Tao, Wei | - |
dc.contributor.author | Ji, Xiaoyuan | - |
dc.date.accessioned | 2022-02-25T13:41:01Z | - |
dc.date.available | 2022-02-25T13:41:01Z | - |
dc.date.created | 2022-02-07 | - |
dc.date.issued | 2021-08-06 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/136866 | - |
dc.description.abstract | The modulation of intracellular reactive oxygen species (ROS) levels is crucial for cellular homeostasis and determination of cellular fate. A sublethal level of ROS sustains cell proliferation, differentiation and promotes tumor metastasis, while a drastic ROS burst directly induces apoptosis. Herein, surface-oxidized arsenene nanosheets (As/AsxOy NSs) with type II heterojunction are fabricated with efficient .O-2(-) and O-1(2) production and glutathione consumption through prolonging the lifetime of photo-excited electron-hole pairs. Moreover, the portion of AsxOy with oxygen vacancies not only catalyzes a Fenton-like reaction, generating .OH and O-2 from H2O2, but also inactivates main anti-oxidants to cut off the "retreat routes" of ROS. After polydopamine (PDA) and cancer cell membrane (M) coating, the engineered As/AsxOy@PDA@M NSs serve as an intelligent theranostic platform with active tumor targeting and long-term blood circulation. Given its narrow-band-gap-enabled in vivo fluorescence imaging properties, As/AsxOy@PDA@M NSs could be applied as an imaging-guided non-invasive and real-time nanomedicine for cancer therapy. Multifunctional materials with a number of effects are important for dealing with the complex environment in cancer therapy. Here, the authors report on surface-oxidized arsenene nanosheets coated with polydopamine and cancer cell membrane as a multi theranostic tumour targeting cancer therapy. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PORTFOLIO | - |
dc.subject | ROS | - |
dc.subject | MECHANISMS | - |
dc.subject | NANOSHEETS | - |
dc.subject | CHEMISTRY | - |
dc.subject | EVOLUTION | - |
dc.subject | STRESS | - |
dc.title | Arsenene-mediated multiple independently targeted reactive oxygen species burst for cancer therapy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jong Seung | - |
dc.identifier.doi | 10.1038/s41467-021-24961-5 | - |
dc.identifier.scopusid | 2-s2.0-85112489654 | - |
dc.identifier.wosid | 000684548700011 | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, v.12, no.1 | - |
dc.relation.isPartOf | NATURE COMMUNICATIONS | - |
dc.citation.title | NATURE COMMUNICATIONS | - |
dc.citation.volume | 12 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | CHEMISTRY | - |
dc.subject.keywordPlus | EVOLUTION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | NANOSHEETS | - |
dc.subject.keywordPlus | ROS | - |
dc.subject.keywordPlus | STRESS | - |
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