Correlating Beta Oscillations from Intraoperative Microelectrode and Postoperative Implanted Electrode in Patients Undergoing Subthalamic Nucleus Deep Brain Stimulation for Parkinson Disease; A Feasibility Study

Abstract

OBJECTIVE: We sought to investigate the feasibility of intraoperative local field potential (LFP) recording from the microelectrode during deep brain stimulation surgery for patients with Parkinson disease. METHODS: Sixteen subthalamic nucleus recordings from 10 Parkinson disease patients who underwent deep brain stimulation surgery were included in this study. Signals from microelectrodes were amplified and differently filtered to display real-time single-unit neuronal activity and LFP simultaneously during surgery. LFP recordings were also recorded postoperatively from the implanted macroelectrodes and, power spectral density and peak frequency of beta oscillation of LFP (beta LFP) between 2 conditions were compared. RESULTS: Stable intraoperative beta LFP were observed in 68.75% (11 of 16) cases. There was no significant difference of peak frequency between intraoperative and postoperative beta-LFP but significant difference of mean percentage of beta LFP was noted between 2 conditions. CONCLUSIONS: Despite low signal-to-noise ratio and susceptibility to noises from external sources, this study shows that intraoperative recording of beta LFP using microelectrode is feasible. And, given that no significant difference in peak frequency of beta LFP between intraoperative and postoperative LFP was found, we suggest that not only intraoperative beta LFP can be used as a reliable surrogate for postoperative beta LFP, but it can also provide us an information for estimating the location with maximal power of beta oscillation within the subthalamic nucleus.