Epigenetic Regulation of Cardiomyocyte Differentiation from Embryonic and Induced Pluripotent Stem Cells
DC Field | Value | Language |
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dc.contributor.author | Kim, Yong-Jin | - |
dc.contributor.author | Tamadon, Amin | - |
dc.contributor.author | Kim, Yoon-Young | - |
dc.contributor.author | Kang, Byeong-Cheol | - |
dc.contributor.author | Ku, Seung-Yup | - |
dc.date.accessioned | 2022-02-26T12:40:50Z | - |
dc.date.available | 2022-02-26T12:40:50Z | - |
dc.date.created | 2022-02-07 | - |
dc.date.issued | 2021-08 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/137014 | - |
dc.description.abstract | With the intent to achieve the best modalities for myocardial cell therapy, different cell types are being evaluated as potent sources for differentiation into cardiomyocytes. Embryonic stem cells and induced pluripotent stem cells have great potential for future progress in the treatment of myocardial diseases. We reviewed aspects of epigenetic mechanisms that play a role in the differentiation of these cells into cardiomyocytes. Cardiomyocytes proliferate during fetal life, and after birth, they undergo permanent terminal differentiation. Upregulation of cardiac-specific genes in adults induces hypertrophy due to terminal differentiation. The repression or expression of these genes is controlled by chromatin structural and epigenetic changes. However, few studies have reviewed and analyzed the epigenetic aspects of the differentiation of embryonic stem cells and induced pluripotent stem cells into cardiac lineage cells. In this review, we focus on the current knowledge of epigenetic regulation of cardiomyocyte proliferation and differentiation from embryonic and induced pluripotent stem cells through histone modification and microRNAs, the maintenance of pluripotency, and its alteration during cardiac lineage differentiation. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | PROMOTES CARDIAC DIFFERENTIATION | - |
dc.subject | CHROMATIN-REMODELING COMPLEXES | - |
dc.subject | HISTONE H3 LYSINE-27 | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | DNA METHYLATION | - |
dc.subject | DEVELOPMENTAL REGULATORS | - |
dc.subject | THERAPEUTIC-EFFICACY | - |
dc.subject | TRANSCRIPTION FACTOR | - |
dc.subject | SMALL-MOLECULE | - |
dc.subject | TARGET GENES | - |
dc.title | Epigenetic Regulation of Cardiomyocyte Differentiation from Embryonic and Induced Pluripotent Stem Cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yong-Jin | - |
dc.identifier.doi | 10.3390/ijms22168599 | - |
dc.identifier.scopusid | 2-s2.0-85112268584 | - |
dc.identifier.wosid | 000689170700001 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.22, no.16 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 22 | - |
dc.citation.number | 16 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | CHROMATIN-REMODELING COMPLEXES | - |
dc.subject.keywordPlus | DEVELOPMENTAL REGULATORS | - |
dc.subject.keywordPlus | DNA METHYLATION | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | HISTONE H3 LYSINE-27 | - |
dc.subject.keywordPlus | PROMOTES CARDIAC DIFFERENTIATION | - |
dc.subject.keywordPlus | SMALL-MOLECULE | - |
dc.subject.keywordPlus | TARGET GENES | - |
dc.subject.keywordPlus | THERAPEUTIC-EFFICACY | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR | - |
dc.subject.keywordAuthor | cardiomyocyte | - |
dc.subject.keywordAuthor | differentiation | - |
dc.subject.keywordAuthor | embryonic stem cell | - |
dc.subject.keywordAuthor | epigenetic markers | - |
dc.subject.keywordAuthor | induced pluripotent stem cell | - |
dc.subject.keywordAuthor | proliferation | - |
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