Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Interactions between NCR(+)ILC3s and the Microbiome in the Airways Shape Asthma SeverityInteractions between NCR + ILC3s and the Microbiome in the Airways Shape Asthma Severity

Other Titles
Interactions between NCR + ILC3s and the Microbiome in the Airways Shape Asthma Severity
Authors
Ham, JonghoKim, JihyunChoi, SungmiPark, JaehyunBaek, Min-gyungKim, Young-ChanSohn, Kyoung-HeeCho, Sang-HeonYang, SiyoungBae, Yong-SooChung, Doo HyunWon, SunghoYi, HanaKang, Hye RyunKim, Hye Young
Issue Date
8월-2021
Publisher
KOREA ASSOC IMMUNOLOGISTS
Keywords
Asthma; Host-microbial interaction; Innate lymphoid cells; Microbiota; Sputum
Citation
IMMUNE NETWORK, v.21, no.4, pp.1 - 16
Indexed
SCIE
SCOPUS
KCI
Journal Title
IMMUNE NETWORK
Volume
21
Number
4
Start Page
1
End Page
16
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/137026
DOI
10.4110/in.2021.21.e25
ISSN
1598-2629
Abstract
Asthma is a heterogeneous disease whose development is shaped by a variety of environmental and genetic factors. While several recent studies suggest that microbial dysbiosis in the gut may promote asthma, little is known about the relationship between the recently discovered lung microbiome and asthma. Innate lymphoid cells (ILCs) have also been shown recently to participate in asthma. To investigate the relationship between the lung microbiome, ILCs, and asthma, we recruited 23 healthy controls (HC), 42 patients with non-severe asthma, and 32 patients with severe asthma. Flow cytometry analysis showed severe asthma associated with fewer natural cytotoxicity receptor (NCR)(+)ILC3s in the lung. Similar changes in other ILC subsets, macrophages, and monocytes were not observed. The asthma patients did not differ from the HC in terms of the alpha and beta-diversity of the lung and gut microbiomes. However, lung function correlated positively with both NCR(+)ILC3 frequencies and microbial diversity in the lung. Sputum NCR(+)ILC3 frequencies correlated positively with lung microbiome diversity in the HC, but this relationship was inversed in severe asthma. Together, these data suggest that airway NCR(+)ILC3s may contribute to a healthy commensal diversity and normal lung function.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Health Sciences > School of Biosystems and Biomedical Sciences > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Yi, Ha na photo

Yi, Ha na
보건과학대학 (바이오시스템의과학부)
Read more

Altmetrics

Total Views & Downloads

BROWSE