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Characteristics of the Molecular Weight of Polyhexamethylene Guanidine (PHMG) Used as a Household Humidifier Disinfectant

Authors
Park, Dong-UkYang, Kee WonKim, JiwonPark, Ju-HyunLee, So-YeonZoh, Kyung EhiKwon, Jung-HwanPark, SoyoungOh, Han Bin
Issue Date
8월-2021
Publisher
MDPI
Keywords
humidifier-disinfectant-associated lung injury (HDLI); molecular mass; number-average molecular weight (M-n); oligomer; polyhexamethylene guanidine (PHMG); polymerization; weight-average molecular weight (M-w)
Citation
MOLECULES, v.26, no.15
Indexed
SCIE
SCOPUS
Journal Title
MOLECULES
Volume
26
Number
15
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/137039
DOI
10.3390/molecules26154490
ISSN
1420-3049
Abstract
(1) Background: Household humidifier disinfectant (HD) brands containing polyhexamethylene guanidine (PHMG) have been found to cause the most HD-associated lung injuries (HDLIs) in the Republic of Korea. Nevertheless, no study has attempted to characterize the potential association of the health effects, including HDLI, with the physicochemical properties of PHMG dissolved in different HD brands. This study aimed to characterize the molecular weight (MW) distribution, the number-average molecular weight (M-n), the weight-average molecular weight (M-w), and the structural types of PHMG used in HD products. (2) Methods: Quantitative measurements were made using matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOF MS). The M-n, M-w,M- and MW distributions were compared among various HD products. (3) Results: The mean M-n and M-w were 542.4 g/mol (range: 403.0-692.2 g/mol) and 560.7 g/mol (range: 424.0-714.70 g/mol), respectively. The degree of PHMG oligomerization ranged from 3 to 7. The MW distribution of PHMG indicated oligomeric compounds regardless of the HD brands. (4) Conclusions: Based on the molecular weight distribution, the average molecular weight of PHMG, and the degree of polymerization, the PHMG collected from HDLI victims could be regarded as an oligomer. PHMG, as used in household humidifiers, should not be exempted from toxic chemical registration as a polymer. Further study is necessary to examine the association of PHMG oligomeric compounds and respiratory health effects, including HDLI.
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생명과학대학 (환경생태공학부)
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