Lignans from Machilus thunbergii as Thymic Stromal Lymphopoietin Inhibitors
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Hyeji | - |
dc.contributor.author | Han, Yoo Kyong | - |
dc.contributor.author | Byun, Youngjoo | - |
dc.contributor.author | Jeon, Young Ho | - |
dc.contributor.author | Lee, Ki Yong | - |
dc.date.accessioned | 2022-02-27T00:40:42Z | - |
dc.date.available | 2022-02-27T00:40:42Z | - |
dc.date.created | 2022-01-20 | - |
dc.date.issued | 2021-08 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/137073 | - |
dc.description.abstract | Thymic stromal lymphopoietin (TSLP) plays an important role in the pathophysiology of various allergic diseases that are mediated by T helper cell type-2 (Th2) responses, including asthma and atopic dermatitis. The primary focus of this study was the identification of potent inhibitors of the TSLP signaling pathway for potential therapeutic use. The 80% methanol extract of Machilus thunbergii bark significantly inhibited the signal transducer and activator of transcription 5 (STAT5) phosphorylation in human mast cell (HMC)-1 cells. Through activity-guided isolation, three lignans (1-3) were obtained and identified as (+)-galbelgin (1), meso-dihydroguaiaretic acid (2), and machilin A (3). Among them, two lignans (1 and 2) significantly inhibited STAT5 phosphorylation and TSLP/TSLPR interaction, as determined by ELISA. Our results indicated that lignans isolated from M. thunbergii are a promising resource for the treatment of allergic diseases. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | MESO-DIHYDROGUAIARETIC ACID | - |
dc.subject | PRIMARY CULTURES | - |
dc.subject | PROTECT | - |
dc.title | Lignans from Machilus thunbergii as Thymic Stromal Lymphopoietin Inhibitors | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Byun, Youngjoo | - |
dc.contributor.affiliatedAuthor | Jeon, Young Ho | - |
dc.contributor.affiliatedAuthor | Lee, Ki Yong | - |
dc.identifier.doi | 10.3390/molecules26164804 | - |
dc.identifier.scopusid | 2-s2.0-85112255534 | - |
dc.identifier.wosid | 000690117800001 | - |
dc.identifier.bibliographicCitation | MOLECULES, v.26, no.16 | - |
dc.relation.isPartOf | MOLECULES | - |
dc.citation.title | MOLECULES | - |
dc.citation.volume | 26 | - |
dc.citation.number | 16 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | MESO-DIHYDROGUAIARETIC ACID | - |
dc.subject.keywordPlus | PRIMARY CULTURES | - |
dc.subject.keywordPlus | PROTECT | - |
dc.subject.keywordAuthor | Machilus thunbergii | - |
dc.subject.keywordAuthor | TSLP | - |
dc.subject.keywordAuthor | STAT5 | - |
dc.subject.keywordAuthor | allergic disease | - |
dc.subject.keywordAuthor | lignan | - |
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