Feasibility and effectiveness of endoscopic irreversible electroporation for the upper gastrointestinal tract: an experimental animal study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeon, Han Jo | - |
dc.contributor.author | Choi, Hyuk Soon | - |
dc.contributor.author | Keum, Bora | - |
dc.contributor.author | Bang, Eun Joo | - |
dc.contributor.author | Lee, Kang Won | - |
dc.contributor.author | Kim, Sang Hyun | - |
dc.contributor.author | Yim, Sun Young | - |
dc.contributor.author | Lee, Jae Min | - |
dc.contributor.author | Kim, Eun Sun | - |
dc.contributor.author | Seo, Yeon Seok | - |
dc.contributor.author | Jeen, Yoon Tae | - |
dc.contributor.author | Lee, Hong Sik | - |
dc.contributor.author | Chun, Hoon Jai | - |
dc.contributor.author | Kim, Hong Bae | - |
dc.contributor.author | Kim, Jong Hyuk | - |
dc.date.accessioned | 2022-02-27T05:41:25Z | - |
dc.date.available | 2022-02-27T05:41:25Z | - |
dc.date.created | 2022-01-20 | - |
dc.date.issued | 2021-07-28 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/137101 | - |
dc.description.abstract | Irreversible electroporation (IRE) is a local non-thermal ablative technique currently used to treat solid tumors. Here, we investigated the clinical potency and safety of IRE with an endoscope in the upper gastrointestinal tract. Pigs were electroporated with recently designed endoscopic IRE catheters in the esophagus, stomach, and duodenum. Two successive strategies were introduced to optimize the electrical energy for the digestive tract. First, each organ was electroporated and the energy upscaled to confirm the upper limit energy inducing improper tissue results, including bleeding and perforation. Excluding the unacceptable energy from the first step, consecutive electroporations were performed with stepwise reductions in energy to identify the energy that damaged each layer. Inceptive research into inappropriate electrical intensity contributed to extensive hemorrhage and bowel perforation for each tissue above a certain energy threshold. However, experiments performed below the precluded energy accompanying hematoxylin and eosin staining and terminal deoxynucleotidyl transferase dUTP nick-end labeling assays showed that damaged mucosal area and depth significantly decreased with decreased energy. Relevant histopathology showed infiltration of inflammatory cells with pyknotic nuclei at the electroporated lesion. This investigation demonstrated the possibility of endoscopic IRE in mucosal dysplasia or early malignant tumors of the hollow viscus. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PORTFOLIO | - |
dc.subject | ARGON PLASMA COAGULATION | - |
dc.subject | RADIOFREQUENCY ABLATION | - |
dc.subject | TISSUE ABLATION | - |
dc.subject | GASTRIC-CANCER | - |
dc.subject | PORCINE | - |
dc.subject | ESOPHAGEAL | - |
dc.subject | EPITHELIUM | - |
dc.subject | IMPEDANCE | - |
dc.subject | CELLS | - |
dc.title | Feasibility and effectiveness of endoscopic irreversible electroporation for the upper gastrointestinal tract: an experimental animal study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Hyuk Soon | - |
dc.contributor.affiliatedAuthor | Lee, Kang Won | - |
dc.contributor.affiliatedAuthor | Yim, Sun Young | - |
dc.contributor.affiliatedAuthor | Lee, Jae Min | - |
dc.contributor.affiliatedAuthor | Kim, Eun Sun | - |
dc.contributor.affiliatedAuthor | Jeen, Yoon Tae | - |
dc.contributor.affiliatedAuthor | Lee, Hong Sik | - |
dc.contributor.affiliatedAuthor | Chun, Hoon Jai | - |
dc.identifier.doi | 10.1038/s41598-021-94583-w | - |
dc.identifier.scopusid | 2-s2.0-85111657866 | - |
dc.identifier.wosid | 000683353600014 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.11, no.1 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 11 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | ARGON PLASMA COAGULATION | - |
dc.subject.keywordPlus | RADIOFREQUENCY ABLATION | - |
dc.subject.keywordPlus | TISSUE ABLATION | - |
dc.subject.keywordPlus | GASTRIC-CANCER | - |
dc.subject.keywordPlus | PORCINE | - |
dc.subject.keywordPlus | ESOPHAGEAL | - |
dc.subject.keywordPlus | EPITHELIUM | - |
dc.subject.keywordPlus | IMPEDANCE | - |
dc.subject.keywordPlus | CELLS | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.