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Plasma level of brain-derived neurotrophic factor (BDNF) in patients with postpartum depression

Authors
Lee, YounjungKim, Kye-HyunLee, Bun-HeeKim, Yong-Ku
Issue Date
13-7월-2021
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Keywords
BDNF; Brain-derived neurotrophic factor; EPDS; Plasma; Postpartum depression
Citation
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v.109
Indexed
SCIE
SCOPUS
Journal Title
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
Volume
109
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/137137
DOI
10.1016/j.pnpbp.2021.110245
ISSN
0278-5846
Abstract
Postpartum depression occurs in 10-15% of mothers. Brain-derived neurotrophic factor (BDNF) is a nerve growth factor that plays a role in neuroplasticity. We hypothesized that the concentration of BDNF is related to reproduction and childbirth, and that women with postpartum depression show alteration in BDNF level. A total of 104 pregnant women was selected as subjects, and 60 non-pregnant women were selected as normal controls. Symptoms of depression were evaluated in the pregnant study subjects using the diagnostic criteria outlined in the Edinburgh Postnatal Depression Scale (EPDS). The pregnant subjects were divided into three groups of perinatal non-depressed controls (n = 61), postpartum depression-recovery (n = 18), and postpartum depression (n = 25). The plasma concentration of BDNF was higher in the pregnant group than in non-pregnant controls and lower in the postpartum depression group at 6 weeks after delivery than in the perinatal non-depressed group. In the postpartum depression-recovery group, the BDNF concentration increased at 6 weeks after delivery compared to that at 24 weeks of gestation. This study found significant changes in plasma BDNF concentration in depressed pregnant women.
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