Self-replicative mRNA-mediated generation of induced pluripotent stem cell line from a 1-year-old Leigh syndrome patient with mitochondrial DNA cytochrome b mutation
DC Field | Value | Language |
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dc.contributor.author | Son, Daryeon | - |
dc.contributor.author | Zheng, Jie | - |
dc.contributor.author | Kim, In Yong | - |
dc.contributor.author | You, Seungkwon | - |
dc.date.accessioned | 2022-02-27T17:41:13Z | - |
dc.date.available | 2022-02-27T17:41:13Z | - |
dc.date.created | 2022-02-15 | - |
dc.date.issued | 2021-07 | - |
dc.identifier.issn | 1873-5061 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/137160 | - |
dc.description.abstract | Leigh syndrome is a progressive neurodegenerative disease due to defects in the mitochondrial genes, including mitochondrial DNA cytochrome b (MTCYB) mutation, that typically begins in infancy or early childhood. Exercise intolerance and fatigue are common symptoms of mitochondrial disorders. Here, we generated induced pluripotent stem cell (iPSC) line from a 1-year-old patient with Leigh syndrome with MTCYB through temporal expression of exogenes, synthetic self-replicative mRNAs which were regulated by B18R protein. The established iPSCs showed expression of various pluripotency markers, a normal karyotype and differentiation potential to three germ layers in vitro while retaining MTCYB mutation. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.title | Self-replicative mRNA-mediated generation of induced pluripotent stem cell line from a 1-year-old Leigh syndrome patient with mitochondrial DNA cytochrome b mutation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | You, Seungkwon | - |
dc.identifier.doi | 10.1016/j.scr.2021.102392 | - |
dc.identifier.scopusid | 2-s2.0-85107291719 | - |
dc.identifier.wosid | 000687656600007 | - |
dc.identifier.bibliographicCitation | STEM CELL RESEARCH, v.54 | - |
dc.relation.isPartOf | STEM CELL RESEARCH | - |
dc.citation.title | STEM CELL RESEARCH | - |
dc.citation.volume | 54 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Cell & Tissue Engineering | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
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