Cardiovascular risks associated with calcium supplementation in patients with osteoporosis: a nationwide cohort study
DC Field | Value | Language |
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dc.contributor.author | Kim, Kyoung Jin | - |
dc.contributor.author | Kim, Min Sun | - |
dc.contributor.author | Hong, Namki | - |
dc.contributor.author | Bae, Jae Hyun | - |
dc.contributor.author | Kim, Kyeong Jin | - |
dc.contributor.author | Kim, Nam Hoon | - |
dc.contributor.author | Rhee, Yumie | - |
dc.contributor.author | Lee, Juneyoung | - |
dc.contributor.author | Kim, Sin Gon | - |
dc.date.accessioned | 2022-02-28T03:42:12Z | - |
dc.date.available | 2022-02-28T03:42:12Z | - |
dc.date.created | 2022-02-28 | - |
dc.date.issued | 2022-09 | - |
dc.identifier.issn | 2055-6837 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/137208 | - |
dc.description.abstract | Aims This study aimed to evaluate the real effects of calcium supplementation on cardiovascular outcomes within a population-based cohort. Methods and results From a nationwide health screening database in South Korea, a total of 11 297 patients with osteoporosis who had taken calcium supplementation with or without vitamin D for at least 90 days [total calcium group; calcium supplementation only (CaO), n = 567; calcium supplementation in combination with vitamin D (CaD), n = 10 730] were matched at a 1:1 ratio to patients who had not taken calcium supplements (control group) by using propensity scores. The overall mean age was 59.9 +/- 8.8 years and the percentage of women was 87.9% in our study population. Over a median follow-up of 54 months, the incidence rate of composite cardiovascular diseases (CVDs) per 1000 person-years was not different between the groups: 9.73 in the total calcium group and 8.97 in the control group [adjusted hazard ratio (HR): 1.12; 95% confidence interval (CI): 0.99-1.28; P = 0.08]. However, calcium supplementation without vitamin D was associated with an increased risk of composite CVD (HR: 1.54; 95% CI: 1.17-2.04; P < 0.01), especially non-fatal myocardial infarction (HR: 1.89; 95% CI: 1.23-2.91; P < 0.01), compared with no calcium supplementation. Conclusion Our population-based study supported that taking calcium supplementation combined with vitamin D did not appear to be harmful to cardiovascular health, but reminded that calcium supplementation without vitamin D should be used carefully even in populations with low dietary calcium intake. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.subject | CORONARY-ARTERY-DISEASE | - |
dc.subject | BONE-MINERAL DENSITY | - |
dc.subject | VITAMIN-D | - |
dc.subject | DIETARY CALCIUM | - |
dc.subject | POSTMENOPAUSAL WOMEN | - |
dc.subject | CONTROLLED-TRIAL | - |
dc.subject | BLOOD-PRESSURE | - |
dc.subject | FRACTURES | - |
dc.subject | MORTALITY | - |
dc.subject | CALCIFICATION | - |
dc.title | Cardiovascular risks associated with calcium supplementation in patients with osteoporosis: a nationwide cohort study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Sin Gon | - |
dc.identifier.doi | 10.1093/ehjcvp/pvab054 | - |
dc.identifier.scopusid | 2-s2.0-85137159415 | - |
dc.identifier.wosid | 000755859000001 | - |
dc.identifier.bibliographicCitation | EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY, v.8, no.6, pp.568 - 577 | - |
dc.relation.isPartOf | EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY | - |
dc.citation.title | EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY | - |
dc.citation.volume | 8 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 568 | - |
dc.citation.endPage | 577 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | CORONARY-ARTERY-DISEASE | - |
dc.subject.keywordPlus | BONE-MINERAL DENSITY | - |
dc.subject.keywordPlus | VITAMIN-D | - |
dc.subject.keywordPlus | DIETARY CALCIUM | - |
dc.subject.keywordPlus | POSTMENOPAUSAL WOMEN | - |
dc.subject.keywordPlus | CONTROLLED-TRIAL | - |
dc.subject.keywordPlus | BLOOD-PRESSURE | - |
dc.subject.keywordPlus | FRACTURES | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | CALCIFICATION | - |
dc.subject.keywordAuthor | Calcium | - |
dc.subject.keywordAuthor | Vitamin D | - |
dc.subject.keywordAuthor | Cardiovascular disease | - |
dc.subject.keywordAuthor | Osteoporosis | - |
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