Multifunctional Tannic Acid-Alendronate Nanocomplexes with Antioxidant, Anti-Inflammatory, and Osteogenic Potency
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Somang | - |
dc.contributor.author | Jo, Han-Saem | - |
dc.contributor.author | Song, Heegyeong | - |
dc.contributor.author | Kim, Hak-Jun | - |
dc.contributor.author | Oh, Jong-Keon | - |
dc.contributor.author | Cho, Jae-Woo | - |
dc.contributor.author | Park, Kyeongsoon | - |
dc.contributor.author | Kim, Sung-Eun | - |
dc.date.accessioned | 2022-02-28T04:41:37Z | - |
dc.date.available | 2022-02-28T04:41:37Z | - |
dc.date.created | 2022-02-09 | - |
dc.date.issued | 2021-07 | - |
dc.identifier.issn | 2079-4991 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/137212 | - |
dc.description.abstract | In the current study, we fabricated tannic acid-alendronate (TA-ALN) nanocomplexes (NPXs) via self-assembly. These TA-ALNs were characterized by dynamic light scattering, zeta potential, transmission electron microscopy, and FT-IR spectroscopy. The TA-ALNs were evaluated for antioxidant, anti-inflammatory, and osteogenesis-accelerating abilities in osteoblast-like cells (MC3T3-E1 cells). All TA-ALNs displayed nano-sized beads that were circular in form. Treatment with TA-ALN (1:0.1) efficiently removed reactive oxygen species in cells and protected osteoblast-like cells from toxic hydrogen peroxide conditions. Moreover, TA-ALN (1:0.1) could markedly decrease the mRNA levels of pro-inflammatory mediators in lipopolysaccharide-stimulated cells. Furthermore, cells treated with TA-ALN (1:1) exhibited not only significantly greater alkaline phosphatase activity and calcium collection, but also outstandingly higher mRNA levels of osteogenesis-related elements such as collagen type I and osteocalcin. These outcomes indicate that the prepared TA-ALNs are excellent for antioxidant, anti-inflammatory, and osteogenic acceleration. Accordingly, TA-ALN can be used latently for bone renovation and regeneration in people with bone fractures, diseases, or disorders. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | ANTICANCER DRUG | - |
dc.subject | NANOPARTICLES | - |
dc.subject | DELIVERY | - |
dc.subject | CELLS | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | MICROSPHERES | - |
dc.subject | SCAFFOLD | - |
dc.subject | RELEASE | - |
dc.title | Multifunctional Tannic Acid-Alendronate Nanocomplexes with Antioxidant, Anti-Inflammatory, and Osteogenic Potency | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hak-Jun | - |
dc.contributor.affiliatedAuthor | Cho, Jae-Woo | - |
dc.contributor.affiliatedAuthor | Kim, Sung-Eun | - |
dc.identifier.doi | 10.3390/nano11071812 | - |
dc.identifier.scopusid | 2-s2.0-85109481842 | - |
dc.identifier.wosid | 000676792200001 | - |
dc.identifier.bibliographicCitation | NANOMATERIALS, v.11, no.7 | - |
dc.relation.isPartOf | NANOMATERIALS | - |
dc.citation.title | NANOMATERIALS | - |
dc.citation.volume | 11 | - |
dc.citation.number | 7 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.subject.keywordPlus | ANTICANCER DRUG | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | MICROSPHERES | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | SCAFFOLD | - |
dc.subject.keywordAuthor | ROS effect | - |
dc.subject.keywordAuthor | alendronate (ALN) | - |
dc.subject.keywordAuthor | inflammation control | - |
dc.subject.keywordAuthor | nanocomplexes (NPXs) | - |
dc.subject.keywordAuthor | osteogenesis acceleration | - |
dc.subject.keywordAuthor | tannic acid (TA) | - |
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