Molecular Mechanism and Prevention Strategy of Chemotherapy- and Radiotherapy-Induced Ovarian Damage
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Seongmin | - |
dc.contributor.author | Kim, Sung-Woo | - |
dc.contributor.author | Han, Soo-Jin | - |
dc.contributor.author | Lee, Sanghoon | - |
dc.contributor.author | Park, Hyun-Tae | - |
dc.contributor.author | Song, Jae-Yun | - |
dc.contributor.author | Kim, Tak | - |
dc.date.accessioned | 2022-02-28T05:41:53Z | - |
dc.date.available | 2022-02-28T05:41:53Z | - |
dc.date.created | 2022-02-09 | - |
dc.date.issued | 2021-07 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/137218 | - |
dc.description.abstract | Fertility preservation is an emerging discipline, which is of substantial clinical value in the care of young patients with cancer. Chemotherapy and radiation may induce ovarian damage in prepubertal girls and young women. Although many studies have explored the mechanisms implicated in ovarian toxicity during cancer treatment, its molecular pathophysiology is not fully understood. Chemotherapy may accelerate follicular apoptosis and follicle reservoir utilization and damage the ovarian stroma via multiple molecular reactions. Oxidative stress and the radiosensitivity of oocytes are the main causes of gonadal damage after radiation treatment. Fertility preservation options can be differentiated by patient age, desire for conception, treatment regimen, socioeconomic status, and treatment duration. This review will help highlight the importance of multidisciplinary oncofertility strategies for providing high-quality care to young female cancer patients. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | ANTI-MULLERIAN HORMONE | - |
dc.subject | ACUTE LYMPHOBLASTIC-LEUKEMIA | - |
dc.subject | ANTRAL FOLLICLE COUNT | - |
dc.subject | GERMLINE STEM-CELLS | - |
dc.subject | ABL TYROSINE KINASE | - |
dc.subject | FERTILITY PRESERVATION | - |
dc.subject | BREAST-CANCER | - |
dc.subject | IN-VITRO | - |
dc.subject | YOUNG-WOMEN | - |
dc.subject | PRIMORDIAL FOLLICLES | - |
dc.title | Molecular Mechanism and Prevention Strategy of Chemotherapy- and Radiotherapy-Induced Ovarian Damage | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Sanghoon | - |
dc.contributor.affiliatedAuthor | Kim, Tak | - |
dc.identifier.doi | 10.3390/ijms22147484 | - |
dc.identifier.scopusid | 2-s2.0-85109790534 | - |
dc.identifier.wosid | 000676430800001 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.22, no.14 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 22 | - |
dc.citation.number | 14 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | ABL TYROSINE KINASE | - |
dc.subject.keywordPlus | ACUTE LYMPHOBLASTIC-LEUKEMIA | - |
dc.subject.keywordPlus | ANTI-MULLERIAN HORMONE | - |
dc.subject.keywordPlus | ANTRAL FOLLICLE COUNT | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | FERTILITY PRESERVATION | - |
dc.subject.keywordPlus | GERMLINE STEM-CELLS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | PRIMORDIAL FOLLICLES | - |
dc.subject.keywordPlus | YOUNG-WOMEN | - |
dc.subject.keywordAuthor | chemotherapy | - |
dc.subject.keywordAuthor | embryo cryopreservation | - |
dc.subject.keywordAuthor | fertility preservation | - |
dc.subject.keywordAuthor | gonadotoxicity | - |
dc.subject.keywordAuthor | oncofertility | - |
dc.subject.keywordAuthor | oocyte cryopreservation | - |
dc.subject.keywordAuthor | oocyte in vitro maturation | - |
dc.subject.keywordAuthor | ovarian suppression | - |
dc.subject.keywordAuthor | ovarian tissue cryopreservation | - |
dc.subject.keywordAuthor | radiotherapy | - |
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