Application of M1 macrophage as a live vector in delivering nanoparticles for in vivo photothermal treatment
DC Field | Value | Language |
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dc.contributor.author | Im, Nu-Ri | - |
dc.contributor.author | Yang, Taeseok Daniel | - |
dc.contributor.author | Park, Kwanjun | - |
dc.contributor.author | Lee, Jang-Hoon | - |
dc.contributor.author | Lee, Jonghwan | - |
dc.contributor.author | Kim, Yoon Hyuck | - |
dc.contributor.author | Lee, Jae-Seung | - |
dc.contributor.author | Kim, Byoungjae | - |
dc.contributor.author | Jung, Kwang-Yoon | - |
dc.contributor.author | Choi, Youngwoon | - |
dc.contributor.author | Baek, Seung-Kuk | - |
dc.date.accessioned | 2022-02-28T07:41:43Z | - |
dc.date.available | 2022-02-28T07:41:43Z | - |
dc.date.created | 2022-02-09 | - |
dc.date.issued | 2021-07 | - |
dc.identifier.issn | 2090-1232 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/137227 | - |
dc.description.abstract | Introduction: To enhance photothermal treatment (PTT) efficiency, a delivery method that uses cell vector for nanoparticles (NPs) delivery has drawn attention and studied widely in recent years. Objectives: In this study, we demonstrated the feasibility of M1 activated macrophage as a live vector for delivering NPs and investigated the effect of NPs loaded M1 stimulated by Lipopolysaccharide on PTT efficiency in vivo. Methods: M1 was used as a live vector for delivering NPs and further to investigate the effect of NPs loaded M1 on PTT efficiency. Non-activated macrophage (M Phi) was stimulated by lipopolysaccharide (LPS) into M1 and assessed for tumor cell phagocytic capacity towards NPs Results: We found M1 exhibited a 20-fold higher uptake capacity of NPs per cell volume and 2.9-fold more active infiltration into the tumor site, compared with non-activated macrophage M Phi. We injected M1 cells peritumorally and observed that these cells penetrated into the tumor mass within 12 h. Then, we conducted PTT using irradiation of a near-infrared laser for 1 min at 1 W/cm(2). As a result, we confirmed that using M1 as an active live vector led to a more rapid reduction in tumor size within 1 day indicating that the efficacy of PTT with NPs-loaded M1 is higher than that with NPs-loaded M Phi. Conclusion: Our study demonstrated the potential role of M1 as a live vector for enhancing the feasibility of PTT in cancer treatment. (C) 2021 The Authors. Published by Elsevier B.V. on behalf of Cairo University. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.subject | POLARIZATION | - |
dc.subject | THERAPY | - |
dc.subject | CANCER | - |
dc.subject | CELL | - |
dc.subject | CHEMOTHERAPY | - |
dc.subject | MODULATION | - |
dc.subject | PLASTICITY | - |
dc.subject | LIPOSOMES | - |
dc.subject | CARCINOMA | - |
dc.subject | GROWTH | - |
dc.title | Application of M1 macrophage as a live vector in delivering nanoparticles for in vivo photothermal treatment | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Jae-Seung | - |
dc.contributor.affiliatedAuthor | Jung, Kwang-Yoon | - |
dc.contributor.affiliatedAuthor | Choi, Youngwoon | - |
dc.contributor.affiliatedAuthor | Baek, Seung-Kuk | - |
dc.identifier.doi | 10.1016/j.jare.2021.01.010 | - |
dc.identifier.scopusid | 2-s2.0-85101341124 | - |
dc.identifier.wosid | 000664399500013 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ADVANCED RESEARCH, v.31, pp.155 - 163 | - |
dc.relation.isPartOf | JOURNAL OF ADVANCED RESEARCH | - |
dc.citation.title | JOURNAL OF ADVANCED RESEARCH | - |
dc.citation.volume | 31 | - |
dc.citation.startPage | 155 | - |
dc.citation.endPage | 163 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | CELL | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | LIPOSOMES | - |
dc.subject.keywordPlus | MODULATION | - |
dc.subject.keywordPlus | PLASTICITY | - |
dc.subject.keywordPlus | POLARIZATION | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordAuthor | Cancer therapy | - |
dc.subject.keywordAuthor | Live cell vector | - |
dc.subject.keywordAuthor | M1 macrophage | - |
dc.subject.keywordAuthor | Medical optics and biotechnology | - |
dc.subject.keywordAuthor | Photothermal effect | - |
dc.subject.keywordAuthor | Photothermal treatment | - |
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