Clinical and genomic assessment of PD-L1 SP142 expression in triple-negative breast cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ahn, Sung Gwe | - |
dc.contributor.author | Kim, Seon-Kyu | - |
dc.contributor.author | Shepherd, Jonathan H. | - |
dc.contributor.author | Cha, Yoon Jin | - |
dc.contributor.author | Bae, Soong June | - |
dc.contributor.author | Kim, Chungyeul | - |
dc.contributor.author | Jeong, Joon | - |
dc.contributor.author | Perou, Charles M. | - |
dc.date.accessioned | 2022-02-28T15:42:41Z | - |
dc.date.available | 2022-02-28T15:42:41Z | - |
dc.date.created | 2021-12-07 | - |
dc.date.issued | 2021-07 | - |
dc.identifier.issn | 0167-6806 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/137271 | - |
dc.description.abstract | Purpose The SP142 PD-L1 assay is a companion diagnostic for atezolizumab in metastatic triple-negative breast cancer (TNBC). We strove to understand the biological, genomic, and clinical characteristics associated with SP142 PD-L1 positivity in TNBC patients. Methods Using 149 TNBC formalin-fixed paraffin-embedded tumor samples, tissue microarray (TMA) and gene expression microarrays were performed in parallel. The VENTANA SP142 assay was used to identify PD-L1 expression from TMA slides. We next generated a gene signature reflective of SP142 status and evaluated signature distribution according to TNBCtype and PAM50 subtypes. A SP142 gene expression signature was identified and was biologically and clinically evaluated on the TNBCs of TCGA, other cohorts, and on other malignancies treated with immune checkpoint inhibitors (ICI). Results Using SP142, 28.9% of samples were PD-L1 protein positive. The SP142 PD-L1-positive TNBC had higher CD8+ T cell percentage, stromal tumor-infiltrating lymphocyte levels, and higher rate of the immunomodulatory TNBCtype compared to PD-L1-negative samples. The recurrence-free survival was prolonged in PD-L1-positive TNBC. The SP142-guided gene expression signature consisted of 94 immune-related genes. The SP142 signature was associated with a higher pathologic complete response rate and better survival in multiple TNBC cohorts. In the TNBC of TCGA, this signature was correlated with lymphocyte-infiltrating signature scores, but not with tumor mutational burden or total neoantigen count. In other malignancies treated with ICIs, the SP142 genomic signature was associated with improved response and survival. Conclusions We provide multi-faceted evidence that SP142 PDL1-positive TNBC have immuno-genomic features characterized as highly lymphocyte-infiltrated and a relatively favorable survival. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.title | Clinical and genomic assessment of PD-L1 SP142 expression in triple-negative breast cancer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Chungyeul | - |
dc.identifier.doi | 10.1007/s10549-021-06193-9 | - |
dc.identifier.scopusid | 2-s2.0-85103353615 | - |
dc.identifier.wosid | 000633348200004 | - |
dc.identifier.bibliographicCitation | BREAST CANCER RESEARCH AND TREATMENT, v.188, no.1, pp.165 - 178 | - |
dc.relation.isPartOf | BREAST CANCER RESEARCH AND TREATMENT | - |
dc.citation.title | BREAST CANCER RESEARCH AND TREATMENT | - |
dc.citation.volume | 188 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 165 | - |
dc.citation.endPage | 178 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | TUMOR-INFILTRATING LYMPHOCYTES | - |
dc.subject.keywordPlus | IMMUNOHISTOCHEMISTRY ASSAYS | - |
dc.subject.keywordPlus | MODELS | - |
dc.subject.keywordAuthor | Triple-negative breast cancer | - |
dc.subject.keywordAuthor | SP142 PD-L1 | - |
dc.subject.keywordAuthor | Tumor-infiltrating lymphocytes | - |
dc.subject.keywordAuthor | Immune-check point inhibitors | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.