Ionic contrast across a lipid membrane for Debye length extension: towards an ultimate bioelectronic transducer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Donggeun | - |
dc.contributor.author | Jung, Woo Hyuk | - |
dc.contributor.author | Lee, Suho | - |
dc.contributor.author | Yu, Eui-Sang | - |
dc.contributor.author | Lee, Taikjin | - |
dc.contributor.author | Kim, Jae Hun | - |
dc.contributor.author | Song, Hyun Seok | - |
dc.contributor.author | Lee, Kwan Hyi | - |
dc.contributor.author | Lee, Seok | - |
dc.contributor.author | Han, Sang-Kook | - |
dc.contributor.author | Choi, Myung Chul | - |
dc.contributor.author | Ahn, Dong June | - |
dc.contributor.author | Ryu, Yong-Sang | - |
dc.contributor.author | Kim, Chulki | - |
dc.date.accessioned | 2022-02-28T20:42:30Z | - |
dc.date.available | 2022-02-28T20:42:30Z | - |
dc.date.created | 2022-02-09 | - |
dc.date.issued | 2021-06-18 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/137296 | - |
dc.description.abstract | Despite technological advances in biomolecule detections, evaluation of molecular interactions via potentiometric devices under ion-enriched solutions has remained a long-standing problem. To avoid severe performance degradation of bioelectronics by ionic screening effects, we cover probe surfaces of field effect transistors with a single film of the supported lipid bilayer, and realize respectable potentiometric signals from receptor-ligand bindings irrespective of ionic strength of bulky solutions by placing an ion-free water layer underneath the supported lipid bilayer. High-energy X-ray reflectometry together with the circuit analysis and molecular dynamics simulation discovered biochemical findings that effective electrical signals dominantly originated from the sub-nanoscale conformational change of lipids in the course of receptor-ligand bindings. Beyond thorough analysis on the underlying mechanism at the molecular level, the proposed supported lipid bilayer-field effect transistor platform ensures the world-record level of sensitivity in molecular detection with excellent reproducibility regardless of molecular charges and environmental ionic conditions. The design of bioelectronic devices that enables accurate detection of biomolecules in ionic solutions at physiologically-relevant concentrations remains a challenge. Here, the authors report a ion-impermeable supported lipid bilayer-assisted field-effect transistor platform for biomolecule detection. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE RESEARCH | - |
dc.subject | ELECTRICAL DETECTION | - |
dc.subject | MOLECULAR-DYNAMICS | - |
dc.subject | DNA HYBRIDIZATION | - |
dc.subject | FIELD | - |
dc.subject | SENSORS | - |
dc.subject | AVIDIN | - |
dc.subject | TRANSISTORS | - |
dc.subject | DISEASE | - |
dc.subject | BINDING | - |
dc.title | Ionic contrast across a lipid membrane for Debye length extension: towards an ultimate bioelectronic transducer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Kwan Hyi | - |
dc.contributor.affiliatedAuthor | Ahn, Dong June | - |
dc.contributor.affiliatedAuthor | Ryu, Yong-Sang | - |
dc.identifier.doi | 10.1038/s41467-021-24122-8 | - |
dc.identifier.scopusid | 2-s2.0-85108080625 | - |
dc.identifier.wosid | 000665038900009 | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, v.12, no.1 | - |
dc.relation.isPartOf | NATURE COMMUNICATIONS | - |
dc.citation.title | NATURE COMMUNICATIONS | - |
dc.citation.volume | 12 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | AVIDIN | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | DNA HYBRIDIZATION | - |
dc.subject.keywordPlus | ELECTRICAL DETECTION | - |
dc.subject.keywordPlus | FIELD | - |
dc.subject.keywordPlus | MOLECULAR-DYNAMICS | - |
dc.subject.keywordPlus | SENSORS | - |
dc.subject.keywordPlus | TRANSISTORS | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
145 Anam-ro, Seongbuk-gu, Seoul, 02841, Korea+82-2-3290-2963
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.