miR-181a-regulated pathways in T-cell differentiation and aging
DC Field | Value | Language |
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dc.contributor.author | Kim, Chulwoo | - |
dc.contributor.author | Ye, Zhongde | - |
dc.contributor.author | Weyand, Cornelia M. | - |
dc.contributor.author | Goronzy, Jorg J. | - |
dc.date.accessioned | 2022-02-28T21:42:40Z | - |
dc.date.available | 2022-02-28T21:42:40Z | - |
dc.date.created | 2021-12-07 | - |
dc.date.issued | 2021-06-15 | - |
dc.identifier.issn | 1742-4933 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/137301 | - |
dc.description.abstract | MicroRNAs (miRNAs) are regulatory noncoding RNAs important for many aspects of cellular processes including cell differentiation and proliferation. Functions of numerous miRNAs have been identified in T cells, with miR-181a regulating T cell activation thresholds during thymic T cell development and during activation of peripheral T cells. Intriguingly, miR-181a is implicated in defective antiviral and vaccine responses in older individuals, as its expression declines in naive T cells with increasing age. Here, we review the pathways that are regulated by miR-181a and that explain the unique role of miR-181a in T cell development, T cell activation and antiviral T cell responses. These studies provide a framework for understanding how a decline in miR-181a expression in T cells could contribute to age-related defects in adaptive immunity. We furthermore review the mechanisms that cause the age-related decline in miR-181a expression and discuss the potential of restoring miR-181a expression or targeting miR-181a-regulated pathways to improve impaired T cell responses in older individuals. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | BMC | - |
dc.subject | DOSE INFLUENZA VACCINE | - |
dc.subject | MIR-181A EXPRESSION | - |
dc.subject | DOUBLE-BLIND | - |
dc.subject | LIFE-SPAN | - |
dc.subject | ACTIVATION | - |
dc.subject | TRANSCRIPTION | - |
dc.subject | RESPONSES | - |
dc.subject | SELECTION | - |
dc.subject | EFFECTOR | - |
dc.subject | AGE | - |
dc.title | miR-181a-regulated pathways in T-cell differentiation and aging | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Chulwoo | - |
dc.identifier.doi | 10.1186/s12979-021-00240-1 | - |
dc.identifier.scopusid | 2-s2.0-85107972953 | - |
dc.identifier.wosid | 000661895100001 | - |
dc.identifier.bibliographicCitation | IMMUNITY & AGEING, v.18, no.1 | - |
dc.relation.isPartOf | IMMUNITY & AGEING | - |
dc.citation.title | IMMUNITY & AGEING | - |
dc.citation.volume | 18 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Geriatrics & Gerontology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Geriatrics & Gerontology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | AGE | - |
dc.subject.keywordPlus | DOSE INFLUENZA VACCINE | - |
dc.subject.keywordPlus | DOUBLE-BLIND | - |
dc.subject.keywordPlus | EFFECTOR | - |
dc.subject.keywordPlus | LIFE-SPAN | - |
dc.subject.keywordPlus | MIR-181A EXPRESSION | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | SELECTION | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordAuthor | Infectious disease | - |
dc.subject.keywordAuthor | Memory T cells | - |
dc.subject.keywordAuthor | Replication stress | - |
dc.subject.keywordAuthor | T cell activation | - |
dc.subject.keywordAuthor | T cell aging | - |
dc.subject.keywordAuthor | T cell differentiation | - |
dc.subject.keywordAuthor | Vaccine | - |
dc.subject.keywordAuthor | miR-181a | - |
dc.subject.keywordAuthor | microRNA | - |
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