HMOC, a chrysin derivative, induces tolerogenic properties in lipopolysaccharide-stimulated dendritic cells
DC Field | Value | Language |
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dc.contributor.author | Song, Ha-Yeon | - |
dc.contributor.author | Kim, Woo Sik | - |
dc.contributor.author | Han, Jeong Moo | - |
dc.contributor.author | Park, Woo Yong | - |
dc.contributor.author | Lim, Seung-Taik | - |
dc.contributor.author | Byun, Eui-Baek | - |
dc.date.accessioned | 2022-03-01T01:41:58Z | - |
dc.date.available | 2022-03-01T01:41:58Z | - |
dc.date.created | 2022-02-09 | - |
dc.date.issued | 2021-06 | - |
dc.identifier.issn | 1567-5769 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/137319 | - |
dc.description.abstract | Although we previously identified a new hydroxymethoxyl chrysin derivative (HMOC) using ionizing radiation, the anti-inflammatory mechanism of HMOC in dendritic cells remains unclear. In this study, we investigate the effects of HMOC on phenotypic and functional changes in activated bone marrow-derived dendritic cells (BMDCs). In lipopolysaccharide (LPS)-stimulated BMDCs, HMOC treatment inhibited pro-inflammatory cytokines (TNF-alpha, IL-12p70, and IL-1 beta), surface molecules (CD80, CD86, MHC-I, and MHC-II), and antigenpresentation to MHC-I and II without a decrease in IL-10. Furthermore, HMOC increased indoleamine 2,3-dioxygenase-1 (IDO1) activity via activation of JNK and p38 signaling in the presence of LPS. Interestingly, LPSstimulated DCs treated with HMOC inhibited the proliferation and activation of CD4+ and CD8+ T cells, as well as differentiation of CD4+ T cells into Th1-, Th2- and Th17 cells. In addition, LPS-stimulated DCs treated with HMOC induced an increase in CD4+CD25+Foxp3+ regulatory T cells (Tregs). Collectively, our results suggest that HMOC confers tolerogenic properties in BMDCs, which are responsible for inducing Th cell differentiation to Tregs. Our findings provide a better understanding of the anti-inflammatory mechanism of HMOC in DCs and may contribute to development of a valuable therapeutic candidate for atopic dermatitis. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.subject | INDOLEAMINE 2,3-DIOXYGENASE | - |
dc.subject | MOLECULAR-MECHANISMS | - |
dc.subject | T-CELLS | - |
dc.subject | SIGNAL | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | IMMUNOTHERAPY | - |
dc.subject | ACTIVATION | - |
dc.subject | CD4(+) | - |
dc.title | HMOC, a chrysin derivative, induces tolerogenic properties in lipopolysaccharide-stimulated dendritic cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lim, Seung-Taik | - |
dc.identifier.doi | 10.1016/j.intimp.2021.107523 | - |
dc.identifier.scopusid | 2-s2.0-85102040148 | - |
dc.identifier.wosid | 000655603100002 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL IMMUNOPHARMACOLOGY, v.95 | - |
dc.relation.isPartOf | INTERNATIONAL IMMUNOPHARMACOLOGY | - |
dc.citation.title | INTERNATIONAL IMMUNOPHARMACOLOGY | - |
dc.citation.volume | 95 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | CD4(+) | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | IMMUNOTHERAPY | - |
dc.subject.keywordPlus | INDOLEAMINE 2,3-DIOXYGENASE | - |
dc.subject.keywordPlus | MOLECULAR-MECHANISMS | - |
dc.subject.keywordPlus | SIGNAL | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordAuthor | 3-Dioxygenase | - |
dc.subject.keywordAuthor | Chrysin derivative | - |
dc.subject.keywordAuthor | Indoleamine 2 | - |
dc.subject.keywordAuthor | Regulatory T cells | - |
dc.subject.keywordAuthor | Tolerogenic dendritic cells | - |
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