Effect of Human or Mouse IL-7 on the Homeostasis of Porcine T Lymphocytes
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hong, Ji Hwa | - |
dc.contributor.author | Kim, Sang Hoon | - |
dc.contributor.author | Kim, Hyun Gyung | - |
dc.contributor.author | Jang, Jun Ho | - |
dc.contributor.author | Son, Ryeo Gang | - |
dc.contributor.author | Pack, Seung Pil | - |
dc.contributor.author | Park, Young-Ho | - |
dc.contributor.author | Kang, Philyong | - |
dc.contributor.author | Jeong, Kang-Jin | - |
dc.contributor.author | Kim, Ji-Su | - |
dc.contributor.author | Choi, Hanbyeul | - |
dc.contributor.author | Kim, Sun-Uk | - |
dc.contributor.author | Jung, Yong Woo | - |
dc.date.accessioned | 2022-03-01T02:41:32Z | - |
dc.date.available | 2022-03-01T02:41:32Z | - |
dc.date.created | 2022-02-09 | - |
dc.date.issued | 2021-06 | - |
dc.identifier.issn | 1598-2629 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/137322 | - |
dc.description.abstract | Due to the inconsistent fluctuation of blood supply for transfusion, much attention has been paid to the development of artificial blood using other animals. Although mini-pigs are candidate animals, contamination of mini-pig T cells in artificial blood may cause a major safety concern. Therefore, it is important to analyze the cross-reactivity of IL-7, the major survival factor for T lymphocytes, between human, mouse, and mini-pig. Thus, we compared the protein sequences of IL-7 and found that porcine IL-7 was evolutionarily different from human IL-7. We also observed that when porcine T cells were cultured with either human or mouse IL-7, these cells did not increase the survival or proliferation compared to negative controls. These results suggest that porcine T cells do not recognize human or mouse IL-7 as their survival factor. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREA ASSOC IMMUNOLOGISTS | - |
dc.subject | VERSUS-HOST-DISEASE | - |
dc.subject | BONE-MARROW | - |
dc.subject | CELLS | - |
dc.subject | GRAFT | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | SURVIVAL | - |
dc.subject | PROLIFERATION | - |
dc.subject | INTERLEUKIN-7 | - |
dc.subject | GENERATION | - |
dc.subject | PIGS | - |
dc.title | Effect of Human or Mouse IL-7 on the Homeostasis of Porcine T Lymphocytes | - |
dc.title.alternative | Effect of Human or Mouse IL-7 on the Homeostasis of Porcine T Lymphocytes | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jung, Yong Woo | - |
dc.identifier.doi | 10.4110/in.2021.21.e24 | - |
dc.identifier.scopusid | 2-s2.0-85111017110 | - |
dc.identifier.wosid | 000670123200007 | - |
dc.identifier.bibliographicCitation | IMMUNE NETWORK, v.21, no.3, pp.1 - 13 | - |
dc.relation.isPartOf | IMMUNE NETWORK | - |
dc.citation.title | IMMUNE NETWORK | - |
dc.citation.volume | 21 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 13 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002737048 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | BONE-MARROW | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | GENERATION | - |
dc.subject.keywordPlus | GRAFT | - |
dc.subject.keywordPlus | INTERLEUKIN-7 | - |
dc.subject.keywordPlus | PIGS | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | VERSUS-HOST-DISEASE | - |
dc.subject.keywordAuthor | Graft-versus-host disease | - |
dc.subject.keywordAuthor | IL-7 | - |
dc.subject.keywordAuthor | Miniature swine | - |
dc.subject.keywordAuthor | T-lymphocytes | - |
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