Rediscovery of nanoparticle-based therapeutics: boosting immunogenic cell death for potential application in cancer immunotherapy
DC Field | Value | Language |
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dc.contributor.author | Yang, Suah | - |
dc.contributor.author | Sun, In-Cheol | - |
dc.contributor.author | Hwang, Hee Sook | - |
dc.contributor.author | Shim, Man Kyu | - |
dc.contributor.author | Yoon, Hong Yeol | - |
dc.contributor.author | Kim, Kwangmeyung | - |
dc.date.accessioned | 2022-03-01T12:41:52Z | - |
dc.date.available | 2022-03-01T12:41:52Z | - |
dc.date.created | 2022-02-09 | - |
dc.date.issued | 2021-05-21 | - |
dc.identifier.issn | 2050-7518 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/137373 | - |
dc.description.abstract | Immunogenic cell death (ICD) occurring by chemical and physical stimuli has shown the potential to activate an adaptive immune response in the immune-competent living body through the release of danger-associated molecular patterns (DAMPs) into the tumor microenvironment (TME). However, limitations to the long-term immune responses and systemic toxicity of conventional ICD inducers have led to unsatisfactory therapeutic efficacy in ICD-based cancer immunotherapy. Until now, various nanoparticle-based ICD-inducers have been developed to induce an antitumor immune response without severe toxicity, and to efficiently elicit an anticancer immune response against target cancer cells. In this review, we introduce a recent advance in the designs and applications of nanoparticle-based therapeutics to elicit ICD for effective cancer immunotherapy. In particular, combination strategies of nanoparticle-based ICD inducers with typical theranostic modalities are introduced intensively. Subsequently, we discuss the expected challenges and future direction of nanoparticle-based ICD inducers to provide strategies for boosting ICD in cancer immunotherapy. These versatile designs and applications of nanoparticle-based therapeutics for ICD can provide advantages to improve the therapeutic efficacy of cancer immunotherapy. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.title | Rediscovery of nanoparticle-based therapeutics: boosting immunogenic cell death for potential application in cancer immunotherapy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Kwangmeyung | - |
dc.identifier.doi | 10.1039/d1tb00397f | - |
dc.identifier.scopusid | 2-s2.0-85106620109 | - |
dc.identifier.wosid | 000644975000001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MATERIALS CHEMISTRY B, v.9, no.19, pp.3983 - 4001 | - |
dc.relation.isPartOf | JOURNAL OF MATERIALS CHEMISTRY B | - |
dc.citation.title | JOURNAL OF MATERIALS CHEMISTRY B | - |
dc.citation.volume | 9 | - |
dc.citation.number | 19 | - |
dc.citation.startPage | 3983 | - |
dc.citation.endPage | 4001 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
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