Comparison of cytotoxicity effects induced by four different types of nanoparticles in human corneal and conjunctival epithelial cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Li, Xiangzhe | - |
dc.contributor.author | Kang, Boram | - |
dc.contributor.author | Eom, Youngsub | - |
dc.contributor.author | Zhong, Jingxiang | - |
dc.contributor.author | Lee, Hyung Keun | - |
dc.contributor.author | Kim, Hyo Myung | - |
dc.contributor.author | Song, Jong Suk | - |
dc.date.accessioned | 2022-03-02T18:42:43Z | - |
dc.date.available | 2022-03-02T18:42:43Z | - |
dc.date.created | 2022-03-02 | - |
dc.date.issued | 2022-01-07 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/137534 | - |
dc.description.abstract | The impact of particulate matter (PM) on ocular surface health has attracted increased attention in recent years. Previous studies have reported that differences in the chemical composition of PM can affect the toxicological response. However, available information on the toxic effects of chemical components of PM on the ocular surface is insufficient. In this paper, we aimed to investigate the toxicity effects of chemical components of PM on the ocular surface, focusing on the effects of four different types of nanoparticles (NPs) in human corneal epithelial cells (HCECs) and human conjunctival epithelial cells (HCjECs), which include titanium dioxide (TiO2), carbon black (CB), zinc dioxide (ZnO), and silicon dioxide (SiO2). We found that the in vitro cytotoxic effects of CB, ZnO, and SiO2 NPs are dependent on particle properties and cell type as well as the exposure concentration and time. Here, the order of increasing toxicity was SiO2 -> CB -> ZnO, while TiO2 demonstrated no toxicity. Moreover, toxic effects appearing more severe in HCECs than HCjECs. Reactive oxygen species (ROS)-mediated oxidative stress plays a key role in the toxicity of these three NPs in HCECs and HCjECs, leading to apoptosis and mitochondrial damage, which are also important contributors to aging. Sirtuin1 (SIRT1) as an NAD+-dependent protein deacetylase that seems to play a potential protective role in this process. These findings implied that ROS and/or SIRT1 may become a potential target of clinical treatment of PM- or NP-related ocular surface diseases. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PORTFOLIO | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | PARTICULATE MATTER | - |
dc.subject | OCULAR SURFACE | - |
dc.subject | DIOXIDE NANOPARTICLES | - |
dc.subject | CHEMICAL-COMPOSITION | - |
dc.subject | AIR-POLLUTION | - |
dc.subject | DNA-DAMAGE | - |
dc.subject | IN-VITRO | - |
dc.subject | SIRT1 | - |
dc.subject | EXPOSURE | - |
dc.title | Comparison of cytotoxicity effects induced by four different types of nanoparticles in human corneal and conjunctival epithelial cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Jong Suk | - |
dc.identifier.doi | 10.1038/s41598-021-04199-3 | - |
dc.identifier.scopusid | 2-s2.0-85122665123 | - |
dc.identifier.wosid | 000740510500228 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.12, no.1 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 12 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | PARTICULATE MATTER | - |
dc.subject.keywordPlus | OCULAR SURFACE | - |
dc.subject.keywordPlus | DIOXIDE NANOPARTICLES | - |
dc.subject.keywordPlus | CHEMICAL-COMPOSITION | - |
dc.subject.keywordPlus | AIR-POLLUTION | - |
dc.subject.keywordPlus | DNA-DAMAGE | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | SIRT1 | - |
dc.subject.keywordPlus | EXPOSURE | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.