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Impaired prepulse inhibition in mice with IRSp53 deletion in modulatory neurotransmitter neurons including dopamine, acetylcholine, oxytocin, and serotonin

Authors
Kim, YangsikYang, EstherKim, Hyun
Issue Date
1-1월-2022
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Keywords
Schizophrenia; Prepulse inhibition; IRSp53; Dopamine; Oxytocin; Serotonin; Acetylcholine
Citation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.586, pp.114 - 120
Indexed
SCIE
SCOPUS
Journal Title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume
586
Start Page
114
End Page
120
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/137536
DOI
10.1016/j.bbrc.2021.11.049
ISSN
0006-291X
Abstract
Prepulse inhibition (PPI) is a neurophysiological finding that is decreased in schizophrenia patients and has been used in pathophysiology studies of schizophrenia and the development of antipsychotic drugs. PPI is affected by several drugs including amphetamine, ketamine, and nicotinic agents, and it is reported that several brain regions and modulatory neurotransmitters are involved in PPI. Here we showed that mice with IRSp53 deletion in each dopaminergic, cholinergic, oxytocinergic, and serotoninergic modulatory neurons showed a decrease in PPI. Other than PPI, there were no other behavioral changes among IRSp53 deletion mice. Through this study, we could reconfirm that dysfunction of each modulatory neuron such as dopamine, acetylcholine, oxytocin, and serotonin can result in PPI impairment, and it should be considered that PPI could be broadly affected by changes in one of a certain kind of modulatory neurons. (c) 2021 Elsevier Inc. All rights reserved.
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