Metabolic Activity of Visceral Adipose Tissue Is Associated with Metastatic Status of Lymph Nodes in Endometrial Cancer: A F-18-FDG PET/CT Study
DC Field | Value | Language |
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dc.contributor.author | Pahk, Kisoo | - |
dc.contributor.author | Ryu, Ki-Jin | - |
dc.contributor.author | Joung, Chanmin | - |
dc.contributor.author | Kwon, Hyun Woo | - |
dc.contributor.author | Lee, Sanghoon | - |
dc.contributor.author | Park, Hyuntae | - |
dc.contributor.author | Kim, Tak | - |
dc.contributor.author | Song, Jae Yun | - |
dc.contributor.author | Kim, Sungeun | - |
dc.date.accessioned | 2022-03-02T20:42:21Z | - |
dc.date.available | 2022-03-02T20:42:21Z | - |
dc.date.created | 2022-03-02 | - |
dc.date.issued | 2022-01 | - |
dc.identifier.issn | 1661-7827 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/137543 | - |
dc.description.abstract | Obesity contributes to increased cancer incidence and aggressiveness in patients with endometrial cancer. Inflamed metabolic activity of visceral adipose tissue (VAT) is regarded as a key underlying mechanism of adverse consequences of obesity. The aim of this study was to investigate the association between inflammatory metabolic activity of VAT evaluated by F-18-fluorodeoxyglucose positron emission tomography/computed tomography (F-18-FDG PET/CT) and metastatic status of lymph nodes (LN) in patients with endometrial cancer. In total, 161 women with newly diagnosed endometrial cancer, who received preoperative 18F-FDG PET/CT, were enrolled. VAT inflammatory metabolic activity was defined as V/S ratio and measured from the maximum standardized uptake value (SUVmax) of VAT normalized to the SUVmax of subcutaneous adipose tissue (SAT). The positive LN metastasis group exhibited a significantly higher V/S ratio than the negative LN metastasis group. Systemic inflammatory surrogate markers including high sensitivity C-reactive protein, spleen SUVmax, and bone marrow SUVmax were also higher in the LN metastasis group than in the negative LN metastasis group, showing significant correlations with V/S ratio. In multivariate logistic regression analysis, V/S ratio was independently associated with LN metastasis. V/S ratio is independently associated with the LN metastasis status in patients with endometrial cancer. This finding could be useful as a potential surrogate marker of obesity-induced VAT inflammation associated with tumor aggressiveness. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | BODY-MASS INDEX | - |
dc.subject | PHYSICAL-ACTIVITY | - |
dc.subject | RISK | - |
dc.subject | MECHANISMS | - |
dc.subject | CARCINOMA | - |
dc.subject | OBESITY | - |
dc.title | Metabolic Activity of Visceral Adipose Tissue Is Associated with Metastatic Status of Lymph Nodes in Endometrial Cancer: A F-18-FDG PET/CT Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Sanghoon | - |
dc.identifier.doi | 10.3390/ijerph19010092 | - |
dc.identifier.scopusid | 2-s2.0-85121450840 | - |
dc.identifier.wosid | 000741310100001 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v.19, no.1 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | - |
dc.citation.title | INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | - |
dc.citation.volume | 19 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | ssci | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Environmental Sciences & Ecology | - |
dc.relation.journalResearchArea | Public, Environmental & Occupational Health | - |
dc.relation.journalWebOfScienceCategory | Environmental Sciences | - |
dc.relation.journalWebOfScienceCategory | Public, Environmental & Occupational Health | - |
dc.subject.keywordPlus | BODY-MASS INDEX | - |
dc.subject.keywordPlus | PHYSICAL-ACTIVITY | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordAuthor | obesity | - |
dc.subject.keywordAuthor | visceral fat | - |
dc.subject.keywordAuthor | endometrial cancer | - |
dc.subject.keywordAuthor | metastasis | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | positron-emission tomography | - |
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